[Association between single-nucleotide polymorphisms in the IRAK-4 gene and allergic rhinitis].

Yuan Zhang, Lin Xi, Yan ming Zhao, Li ping Zhao, Luo Zhang

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

To investigate the genetic association pattern between single-nucleotide polymorphisms (SNP) in the interleukin-1 receptor-associated kinase 4 (IRAK-4) gene and allergic rhinitis (AR). A population of 379 patients with the diagnosis of AR and 333 healthy controls who lived in Beijing region was recruited. A total of 8 reprehensive marker SNP which were in IRAK-4 gene region were selected according to the Beijing people database from Hapmap website. The individual genotyping was performed by MassARRAY platform. SPSS 13.0 software was used for statistic analysis. Subgroup analysis for the presence of different allergen sensitivities displayed associations only in the house dust mite-allergic cohorts (rs3794262: P = 0.0034, OR = 1.7388; rs4251481: P = 0.0023, OR = 2.6593), but not in subjects who were allergic to pollens as well as mix allergens. The potential genetic contribution of the IRAK-4 gene to AR demonstrated an allergen-dependant association pattern in Chinese population.

Original languageEnglish (US)
Pages (from-to)476-480
Number of pages5
JournalZhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
Volume47
Issue number6
StatePublished - Jun 2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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