Association of β-Lactam Allergy Documentation and Prophylactic Antibiotic Use in Surgery: A National Cross-Sectional Study of Hospitalized Patients

Christie M. Bertram; Michael Postelnick; Christian M. Mancini; Xiaoqing Fu; Yuqing Zhang; Lucas T. Schulz; Tanaya Bhowmick; Francesca Lee; Kimberly G. Blumenthal

doi:10.1093/cid/ciaa1762

Association of β-Lactam Allergy Documentation and Prophylactic Antibiotic Use in Surgery: A National Cross-Sectional Study of Hospitalized Patients

Christie M. Bertram, Michael Postelnick, Christian M. Mancini, Xiaoqing Fu, Yuqing Zhang, Lucas T. Schulz, Tanaya Bhowmick, Francesca Lee, Kimberly G. Blumenthal

Robert Wood Johnson Medical School (RWJMS), Medicine, Division of Infectious Disease

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Alternative antibiotics for surgical prophylaxis are associated with increased adverse events and surgical site infection compared to cefazolin. In a sample of perioperative inpatients from 100 hospitals in the United States, cefazolin was 9-fold less likely to be used in patients with a documented β-lactam allergy whereas clindamycin was 45-fold more likely.

Original language	English (US)
Pages (from-to)	E872-E875
Journal	Clinical Infectious Diseases
Volume	72
Issue number	11
DOIs	https://doi.org/10.1093/cid/ciaa1762
State	Published - Jun 1 2021

All Science Journal Classification (ASJC) codes

Microbiology (medical)
Infectious Diseases

Keywords

allergy
antibiotic
surgical prophylaxis
β-lactam

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10.1093/cid/ciaa1762

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title = "Association of β-Lactam Allergy Documentation and Prophylactic Antibiotic Use in Surgery: A National Cross-Sectional Study of Hospitalized Patients",

abstract = "Alternative antibiotics for surgical prophylaxis are associated with increased adverse events and surgical site infection compared to cefazolin. In a sample of perioperative inpatients from 100 hospitals in the United States, cefazolin was 9-fold less likely to be used in patients with a documented β-lactam allergy whereas clindamycin was 45-fold more likely.",

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AU - Postelnick, Michael

AU - Mancini, Christian M.

AU - Fu, Xiaoqing

AU - Zhang, Yuqing

AU - Schulz, Lucas T.

AU - Bhowmick, Tanaya

AU - Lee, Francesca

AU - Blumenthal, Kimberly G.

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AB - Alternative antibiotics for surgical prophylaxis are associated with increased adverse events and surgical site infection compared to cefazolin. In a sample of perioperative inpatients from 100 hospitals in the United States, cefazolin was 9-fold less likely to be used in patients with a documented β-lactam allergy whereas clindamycin was 45-fold more likely.

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KW - β-lactam

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ER -

Association of β-Lactam Allergy Documentation and Prophylactic Antibiotic Use in Surgery: A National Cross-Sectional Study of Hospitalized Patients

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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