Association of catechol-O-methyltransferase with smoking cessation in two independent studies of women

Susan Colilla, Caryn Lerman, Peter G. Shields, Christopher Jepson, Margaret Rukstalis, Jesse Berlin, Angela DeMichele, Greta Bunin, Brian L. Strom, Timothy R. Rebbeck

Research output: Contribution to journalArticlepeer-review

80 Scopus citations

Abstract

Objectives and methods: The Val108/158Met polymorphism in the gene that encodes COMT, a dopamine metabolizing enzyme, results in a three- to four-fold reduction in COMT activity. To determine if the lower activity Met allele of COMT was associated with smoking cessation in women, we used two independent studies: a population-based case-control study and a nicotine replacement clinical trial. Results: In the case-control study, women with two Met alleles were significantly more likely to be ex-smokers than current smokers [OR=1.82, 95% CI (1.05, 3.17), P=0.03]. In the nicotine replacement clinical trial, among women, the Met/Met genotype was associated with a higher probability of smoking cessation based on both point prevalence and prolonged abstinence outcomes [OR = 2.96, 95% CI (1.07, 8.14), P=0.04; OR=3.23, 95% CI (1.13, 9.20), P=0.03, respectively]. Conclusions: This first report of a significant association between COMT Val108/158Met and smoking cessation suggests that COMT variation has an effect on smoking behavior in women.

Original languageEnglish (US)
Pages (from-to)393-398
Number of pages6
JournalPharmacogenetics and Genomics
Volume15
Issue number6
DOIs
StatePublished - Jun 2005

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Keywords

  • COMT
  • Pharmacogenetics
  • Smoking cessation
  • Tobacco dependence
  • Women

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