Association of High-Risk Human Papillomavirus with Genital Tract Mucosal Immune Factors in HIV-Infected Women

Niall Buckley; Ashley Huber; Yungtai Lo; Philip E. Castle; Kimdar Kemal; Robert D. Burk; Howard D. Strickler; Mark H. Einstein; Mary Young; Kathryn Anastos; Betsy C. Herold

doi:10.1111/aji.12461

Association of High-Risk Human Papillomavirus with Genital Tract Mucosal Immune Factors in HIV-Infected Women

Niall Buckley, Ashley Huber, Yungtai Lo, Philip E. Castle, Kimdar Kemal, Robert D. Burk, Howard D. Strickler, Mark H. Einstein, Mary Young, Kathryn Anastos, Betsy C. Herold

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Problem: High-risk human papillomavirus (HR-HPV) is prevalent in HIV-infected women and may be associated with mucosal changes that promote HIV replication. Method of study: Innate immune molecules, antimicrobial activity, HIV RNA, and HPV DNA genotypes were measured in a cross-sectional study of 128 HIV-infected women categorized into HPV-16 (n = 8), other HR-HPV (n = 41), and non-HR-HPV controls (n = 79). Results: Compared to controls, HR-HPV groups had higher plasma viral loads (P = 0.004), lower CD4 cells (P = 0.02), more genital tract HIV RNA (P = 0.03), greater number of different HPV types (P < 0.001), higher cervicovaginal lavage (CVL) IL-1α (P = 0.03) and human beta-defensin 2 (HBD2) (P = 0.049), and less anti-HIV_B_al activity (P = 0.03). HPV-16 remained significantly associated with higher HBD2 (P = 0.03), higher IL-1α (P = 0.009), and lower anti-HIV_B_aL activity (P = 0.03) compared to controls after adjusting for plasma viral load and CD4 T cell count. Conclusion: HR-HPV is associated with mucosal changes in HIV-infected women that could adversely impact genital tract health.

Original language	English (US)
Pages (from-to)	146-154
Number of pages	9
Journal	American Journal of Reproductive Immunology
Volume	75
Issue number	2
DOIs	https://doi.org/10.1111/aji.12461
State	Published - Feb 1 2016
Externally published	Yes

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology
Reproductive Medicine
Obstetrics and Gynecology

Keywords

Cervicovaginal immunity
Defensins
HIV
Human papillomavirus

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10.1111/aji.12461

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title = "Association of High-Risk Human Papillomavirus with Genital Tract Mucosal Immune Factors in HIV-Infected Women",

abstract = "Problem: High-risk human papillomavirus (HR-HPV) is prevalent in HIV-infected women and may be associated with mucosal changes that promote HIV replication. Method of study: Innate immune molecules, antimicrobial activity, HIV RNA, and HPV DNA genotypes were measured in a cross-sectional study of 128 HIV-infected women categorized into HPV-16 (n = 8), other HR-HPV (n = 41), and non-HR-HPV controls (n = 79). Results: Compared to controls, HR-HPV groups had higher plasma viral loads (P = 0.004), lower CD4 cells (P = 0.02), more genital tract HIV RNA (P = 0.03), greater number of different HPV types (P < 0.001), higher cervicovaginal lavage (CVL) IL-1α (P = 0.03) and human beta-defensin 2 (HBD2) (P = 0.049), and less anti-HIVBal activity (P = 0.03). HPV-16 remained significantly associated with higher HBD2 (P = 0.03), higher IL-1α (P = 0.009), and lower anti-HIVBaL activity (P = 0.03) compared to controls after adjusting for plasma viral load and CD4 T cell count. Conclusion: HR-HPV is associated with mucosal changes in HIV-infected women that could adversely impact genital tract health.",

keywords = "Cervicovaginal immunity, Defensins, HIV, Human papillomavirus",

author = "Niall Buckley and Ashley Huber and Yungtai Lo and Castle, \{Philip E.\} and Kimdar Kemal and Burk, \{Robert D.\} and Strickler, \{Howard D.\} and Einstein, \{Mark H.\} and Mary Young and Kathryn Anastos and Herold, \{Betsy C.\}",

note = "Publisher Copyright: {\textcopyright} 2016 John Wiley \& Sons A/S.",

year = "2016",

month = feb,

day = "1",

doi = "10.1111/aji.12461",

language = "English (US)",

volume = "75",

pages = "146--154",

journal = "American Journal of Reproductive Immunology",

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TY - JOUR

T1 - Association of High-Risk Human Papillomavirus with Genital Tract Mucosal Immune Factors in HIV-Infected Women

AU - Buckley, Niall

AU - Huber, Ashley

AU - Lo, Yungtai

AU - Castle, Philip E.

AU - Kemal, Kimdar

AU - Burk, Robert D.

AU - Strickler, Howard D.

AU - Einstein, Mark H.

AU - Young, Mary

AU - Anastos, Kathryn

AU - Herold, Betsy C.

PY - 2016/2/1

Y1 - 2016/2/1

N2 - Problem: High-risk human papillomavirus (HR-HPV) is prevalent in HIV-infected women and may be associated with mucosal changes that promote HIV replication. Method of study: Innate immune molecules, antimicrobial activity, HIV RNA, and HPV DNA genotypes were measured in a cross-sectional study of 128 HIV-infected women categorized into HPV-16 (n = 8), other HR-HPV (n = 41), and non-HR-HPV controls (n = 79). Results: Compared to controls, HR-HPV groups had higher plasma viral loads (P = 0.004), lower CD4 cells (P = 0.02), more genital tract HIV RNA (P = 0.03), greater number of different HPV types (P < 0.001), higher cervicovaginal lavage (CVL) IL-1α (P = 0.03) and human beta-defensin 2 (HBD2) (P = 0.049), and less anti-HIVBal activity (P = 0.03). HPV-16 remained significantly associated with higher HBD2 (P = 0.03), higher IL-1α (P = 0.009), and lower anti-HIVBaL activity (P = 0.03) compared to controls after adjusting for plasma viral load and CD4 T cell count. Conclusion: HR-HPV is associated with mucosal changes in HIV-infected women that could adversely impact genital tract health.

AB - Problem: High-risk human papillomavirus (HR-HPV) is prevalent in HIV-infected women and may be associated with mucosal changes that promote HIV replication. Method of study: Innate immune molecules, antimicrobial activity, HIV RNA, and HPV DNA genotypes were measured in a cross-sectional study of 128 HIV-infected women categorized into HPV-16 (n = 8), other HR-HPV (n = 41), and non-HR-HPV controls (n = 79). Results: Compared to controls, HR-HPV groups had higher plasma viral loads (P = 0.004), lower CD4 cells (P = 0.02), more genital tract HIV RNA (P = 0.03), greater number of different HPV types (P < 0.001), higher cervicovaginal lavage (CVL) IL-1α (P = 0.03) and human beta-defensin 2 (HBD2) (P = 0.049), and less anti-HIVBal activity (P = 0.03). HPV-16 remained significantly associated with higher HBD2 (P = 0.03), higher IL-1α (P = 0.009), and lower anti-HIVBaL activity (P = 0.03) compared to controls after adjusting for plasma viral load and CD4 T cell count. Conclusion: HR-HPV is associated with mucosal changes in HIV-infected women that could adversely impact genital tract health.

KW - Cervicovaginal immunity

KW - Defensins

KW - HIV

KW - Human papillomavirus

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JF - American Journal of Reproductive Immunology

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ER -

Association of High-Risk Human Papillomavirus with Genital Tract Mucosal Immune Factors in HIV-Infected Women

Abstract

All Science Journal Classification (ASJC) codes

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