TY - JOUR
T1 - Association of High-Risk Human Papillomavirus with Genital Tract Mucosal Immune Factors in HIV-Infected Women
AU - Buckley, Niall
AU - Huber, Ashley
AU - Lo, Yungtai
AU - Castle, Philip E.
AU - Kemal, Kimdar
AU - Burk, Robert D.
AU - Strickler, Howard D.
AU - Einstein, Mark H.
AU - Young, Mary
AU - Anastos, Kathryn
AU - Herold, Betsy C.
N1 - Funding Information:
Data in this manuscript were collected at the Bronx/Manhattan Consortium and Washington DC Metropolitan Consortium sites of the Women''s Interagency HIV Study (WIHS) Collaborative Study Group (U01-AI-035004 and U01-AI-034994). The WIHS is funded by the National Institute of Allergy and Infectious Diseases and by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (UO1-HD-32632). This study was also supported by U19AI103461, R01AI065309, R33AI079763, NIH-51519 (Center for AIDS Research at the Albert Einstein College of Medicine and Montefiore Medical Center), and P30AI050409 (Emory Center for AIDS Research ). Additional support for HPV testing was provided by R01CA85178 (Strickler). The contents are solely the responsibility of the authors.
Publisher Copyright:
© 2016 John Wiley & Sons A/S.
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Problem: High-risk human papillomavirus (HR-HPV) is prevalent in HIV-infected women and may be associated with mucosal changes that promote HIV replication. Method of study: Innate immune molecules, antimicrobial activity, HIV RNA, and HPV DNA genotypes were measured in a cross-sectional study of 128 HIV-infected women categorized into HPV-16 (n = 8), other HR-HPV (n = 41), and non-HR-HPV controls (n = 79). Results: Compared to controls, HR-HPV groups had higher plasma viral loads (P = 0.004), lower CD4 cells (P = 0.02), more genital tract HIV RNA (P = 0.03), greater number of different HPV types (P < 0.001), higher cervicovaginal lavage (CVL) IL-1α (P = 0.03) and human beta-defensin 2 (HBD2) (P = 0.049), and less anti-HIVBal activity (P = 0.03). HPV-16 remained significantly associated with higher HBD2 (P = 0.03), higher IL-1α (P = 0.009), and lower anti-HIVBaL activity (P = 0.03) compared to controls after adjusting for plasma viral load and CD4 T cell count. Conclusion: HR-HPV is associated with mucosal changes in HIV-infected women that could adversely impact genital tract health.
AB - Problem: High-risk human papillomavirus (HR-HPV) is prevalent in HIV-infected women and may be associated with mucosal changes that promote HIV replication. Method of study: Innate immune molecules, antimicrobial activity, HIV RNA, and HPV DNA genotypes were measured in a cross-sectional study of 128 HIV-infected women categorized into HPV-16 (n = 8), other HR-HPV (n = 41), and non-HR-HPV controls (n = 79). Results: Compared to controls, HR-HPV groups had higher plasma viral loads (P = 0.004), lower CD4 cells (P = 0.02), more genital tract HIV RNA (P = 0.03), greater number of different HPV types (P < 0.001), higher cervicovaginal lavage (CVL) IL-1α (P = 0.03) and human beta-defensin 2 (HBD2) (P = 0.049), and less anti-HIVBal activity (P = 0.03). HPV-16 remained significantly associated with higher HBD2 (P = 0.03), higher IL-1α (P = 0.009), and lower anti-HIVBaL activity (P = 0.03) compared to controls after adjusting for plasma viral load and CD4 T cell count. Conclusion: HR-HPV is associated with mucosal changes in HIV-infected women that could adversely impact genital tract health.
KW - Cervicovaginal immunity
KW - Defensins
KW - HIV
KW - Human papillomavirus
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U2 - 10.1111/aji.12461
DO - 10.1111/aji.12461
M3 - Article
C2 - 26685115
AN - SCOPUS:84956715627
VL - 75
SP - 146
EP - 154
JO - American Journal of Reproductive Immunology
JF - American Journal of Reproductive Immunology
SN - 1046-7408
IS - 2
ER -