Abstract
Problem: High-risk human papillomavirus (HR-HPV) is prevalent in HIV-infected women and may be associated with mucosal changes that promote HIV replication. Method of study: Innate immune molecules, antimicrobial activity, HIV RNA, and HPV DNA genotypes were measured in a cross-sectional study of 128 HIV-infected women categorized into HPV-16 (n = 8), other HR-HPV (n = 41), and non-HR-HPV controls (n = 79). Results: Compared to controls, HR-HPV groups had higher plasma viral loads (P = 0.004), lower CD4 cells (P = 0.02), more genital tract HIV RNA (P = 0.03), greater number of different HPV types (P < 0.001), higher cervicovaginal lavage (CVL) IL-1α (P = 0.03) and human beta-defensin 2 (HBD2) (P = 0.049), and less anti-HIVBal activity (P = 0.03). HPV-16 remained significantly associated with higher HBD2 (P = 0.03), higher IL-1α (P = 0.009), and lower anti-HIVBaL activity (P = 0.03) compared to controls after adjusting for plasma viral load and CD4 T cell count. Conclusion: HR-HPV is associated with mucosal changes in HIV-infected women that could adversely impact genital tract health.
Original language | English (US) |
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Pages (from-to) | 146-154 |
Number of pages | 9 |
Journal | American Journal of Reproductive Immunology |
Volume | 75 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1 2016 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Immunology and Allergy
- Immunology
- Reproductive Medicine
- Obstetrics and Gynecology
Keywords
- Cervicovaginal immunity
- Defensins
- HIV
- Human papillomavirus