Association of prenatal perchlorate, thiocyanate, and nitrate exposure with neonatal size and gestational age

Kristin A. Evans, David Q. Rich, Barry Weinberger, Anna M. Vetrano, Liza Valentin-Blasini, Pamela Ohman Strickland, Benjamin C. Blount

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Background: Perchlorate and similar anions compete with iodine for uptake into the thyroid by the sodium iodide symporter (NIS). This may restrict fetal growth via impaired thyroid hormone production. Methods: We collected urine samples from 107 pregnant women and used linear regression to estimate differences in newborn size and gestational age associated with increases in perchlorate, thiocyanate, nitrate, and perchlorate equivalence concentrations (PEC; measure of total NIS inhibitor exposure). Results: NIS inhibitor concentrations were not associated with newborn weight, length, or gestational age. Each 2.62 ng/μg creatinine increase in perchlorate was associated with smaller head circumference (0.32 cm; 95% CI: -0.66, 0.01), but each 3.38 ng/μg increase in PEC was associated with larger head circumference (0.48 cm; -0.01, 0.97). Conclusions: These anions may have effects on fetal development (e.g. neurocognitive) that are not reflected in gross measures. Future research should focus on other abnormalities in neonates exposed to NIS inhibitors.

Original languageEnglish (US)
Pages (from-to)183-189
Number of pages7
JournalReproductive Toxicology
Volume57
DOIs
StatePublished - Nov 1 2015

All Science Journal Classification (ASJC) codes

  • Toxicology

Keywords

  • Birth weight
  • NIS inhibitors
  • Nitrate
  • Perchlorate
  • Prenatal
  • Thiocyanate

Fingerprint Dive into the research topics of 'Association of prenatal perchlorate, thiocyanate, and nitrate exposure with neonatal size and gestational age'. Together they form a unique fingerprint.

Cite this