Association of salivary bacterial aggregating activity with sulfomucin

J. Piotrowski, V. L.N. Murty, A. Czajkowski, A. Slomiany, F. Yotsumoto, J. Majka, B. L. Slomiany

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


The requirements of human salivary mucins for aggregating potential towards the common cariogenic oral bacteria, S. mutans and S. sanguis, were investigated. Agglutination inhibition assays demonstrated that the aggregating capacity towards bacteria resides in the acidic mucin fraction. The inhibitory activity of the acidic mucin decreased only 2-4-fold following removal of sialic acid, whereas the desulfation caused a complete loss of the inhibitory potential against both bacteria. Furthermore, the aggregating capacity of mucin-derived sulfated oligosaccharide was found to be 16-fold higher than that of the sialic acid containing oligosaccharide. The results point towards the importance of salivary sulfomucins as a predominant factor in the defense of oral cavity against cariogenic bacteria.

Original languageEnglish (US)
Pages (from-to)713-721
Number of pages9
JournalBiochemistry and Molecular Biology International
Issue number4
StatePublished - 1994

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Genetics


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