Association of the ε4 allele of apolipoprotein E with poor performance on a dementia screen in African Americans

Siu L. Hui; Sujuan Gao; Kathleen S. Hall; Amrik Sahota; Hugh C. Hendrie

Association of the ε4 allele of apolipoprotein E with poor performance on a dementia screen in African Americans

Siu L. Hui, Sujuan Gao, Kathleen S. Hall, Amrik Sahota, Hugh C. Hendrie

Research output: Contribution to journal › Article › peer-review

Abstract

In a community-based study of Alzheimer's disease in African Americans age 65 and over, subjects were classified into three levels of performance based on their scores as measured by the Community Screening Instrument for Dementia (CSI"D"), consisting of cognitive and functioning components. In a subset of 268 subjects with apolipoprotein E (APOE) genotype data, we found that the ε4 allele of APOE was associated with intermediate/poor performance (single copy ε4 odds ratio 1.51, 95% CI 1.18 to 1.92; double copy ε4 odds ratio 3.42, 95% CI 2.18 to 5.43). From these data, we believe it would be possible to conduct population screening for the effects of possession of the APOE-ε4 allele using information derived from the CSI"D".

Original language	English (US)
Pages (from-to)	266-271
Number of pages	6
Journal	Ethnicity and Disease
Volume	6
Issue number	3-4
State	Published - Sep 1996
Externally published	Yes

All Science Journal Classification (ASJC) codes

Epidemiology

Keywords

APOE
African Americans and Community Survey
Apolipoprotein E
Cognitive Function
Dementia

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title = "Association of the ε4 allele of apolipoprotein E with poor performance on a dementia screen in African Americans",

abstract = "In a community-based study of Alzheimer's disease in African Americans age 65 and over, subjects were classified into three levels of performance based on their scores as measured by the Community Screening Instrument for Dementia (CSI{"}D{"}), consisting of cognitive and functioning components. In a subset of 268 subjects with apolipoprotein E (APOE) genotype data, we found that the ε4 allele of APOE was associated with intermediate/poor performance (single copy ε4 odds ratio 1.51, 95% CI 1.18 to 1.92; double copy ε4 odds ratio 3.42, 95% CI 2.18 to 5.43). From these data, we believe it would be possible to conduct population screening for the effects of possession of the APOE-ε4 allele using information derived from the CSI{"}D{"}.",

keywords = "APOE, African Americans and Community Survey, Apolipoprotein E, Cognitive Function, Dementia",

author = "Hui, {Siu L.} and Sujuan Gao and Hall, {Kathleen S.} and Amrik Sahota and Hendrie, {Hugh C.}",

year = "1996",

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T1 - Association of the ε4 allele of apolipoprotein E with poor performance on a dementia screen in African Americans

AU - Hui, Siu L.

AU - Gao, Sujuan

AU - Hall, Kathleen S.

AU - Sahota, Amrik

AU - Hendrie, Hugh C.

PY - 1996/9

Y1 - 1996/9

N2 - In a community-based study of Alzheimer's disease in African Americans age 65 and over, subjects were classified into three levels of performance based on their scores as measured by the Community Screening Instrument for Dementia (CSI"D"), consisting of cognitive and functioning components. In a subset of 268 subjects with apolipoprotein E (APOE) genotype data, we found that the ε4 allele of APOE was associated with intermediate/poor performance (single copy ε4 odds ratio 1.51, 95% CI 1.18 to 1.92; double copy ε4 odds ratio 3.42, 95% CI 2.18 to 5.43). From these data, we believe it would be possible to conduct population screening for the effects of possession of the APOE-ε4 allele using information derived from the CSI"D".

AB - In a community-based study of Alzheimer's disease in African Americans age 65 and over, subjects were classified into three levels of performance based on their scores as measured by the Community Screening Instrument for Dementia (CSI"D"), consisting of cognitive and functioning components. In a subset of 268 subjects with apolipoprotein E (APOE) genotype data, we found that the ε4 allele of APOE was associated with intermediate/poor performance (single copy ε4 odds ratio 1.51, 95% CI 1.18 to 1.92; double copy ε4 odds ratio 3.42, 95% CI 2.18 to 5.43). From these data, we believe it would be possible to conduct population screening for the effects of possession of the APOE-ε4 allele using information derived from the CSI"D".

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