Asymptomatic bacteriuria in pregestational diabetic pregnancies and the role of group B streptococcus

Jesus R. Alvarez, Adam J. Fechner, Shauna Williams, Vijaya L. Ganesh, Joseph Apuzzio

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

We sought to determine if gravidas with pregestational diabetes mellitus (DM) are at increased risk for asymptomatic bacteriuria (ASB) compared with nondiabetic gravidas. This is a retrospective case-control study of 150 pregnant patients with pregestational DM and 294 nondiabetic controls. Rates of ASB and any colony count of group B streptococcus (GBS) bacteriuria were reviewed. The incidence of ASB among pregestational diabetics was higher compared with nondiabetic gravidas (18% versus 8.2%, odds ratio [OR] 2.47, 95% confidence interval [CI] 1.37 to 4.45). GBS was the most common organism in diabetic gravidas (26%). There was no difference in incidence of ASB recurrence (OR 1.26, 95% CI 0.37 to 4.36), but antibiotic resistance was higher in the control group (OR 0.28, 95% CI 0.09 to 0.91). Diabetic gravidas with ASB or any level of GBS bacteriuria had higher hemoglobin A1c values compared with diabetics without ASB (8.31±1.89 versus 7.31±1.84, p=0.0035). Our results demonstrate that gravidas with DM are at increased risk of ASB including GBS bacteriuria compared with non-diabetic gravidas.

Original languageEnglish (US)
Pages (from-to)231-234
Number of pages4
JournalAmerican Journal of Perinatology
Volume27
Issue number3
DOIs
StatePublished - Mar 4 2010

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Pregnancy in Diabetics
Bacteriuria
Streptococcus agalactiae
Diabetes Mellitus
Odds Ratio
Confidence Intervals
Incidence
Microbial Drug Resistance
Case-Control Studies
Hemoglobins

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology
  • Pediatrics, Perinatology, and Child Health

Cite this

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title = "Asymptomatic bacteriuria in pregestational diabetic pregnancies and the role of group B streptococcus",
abstract = "We sought to determine if gravidas with pregestational diabetes mellitus (DM) are at increased risk for asymptomatic bacteriuria (ASB) compared with nondiabetic gravidas. This is a retrospective case-control study of 150 pregnant patients with pregestational DM and 294 nondiabetic controls. Rates of ASB and any colony count of group B streptococcus (GBS) bacteriuria were reviewed. The incidence of ASB among pregestational diabetics was higher compared with nondiabetic gravidas (18{\%} versus 8.2{\%}, odds ratio [OR] 2.47, 95{\%} confidence interval [CI] 1.37 to 4.45). GBS was the most common organism in diabetic gravidas (26{\%}). There was no difference in incidence of ASB recurrence (OR 1.26, 95{\%} CI 0.37 to 4.36), but antibiotic resistance was higher in the control group (OR 0.28, 95{\%} CI 0.09 to 0.91). Diabetic gravidas with ASB or any level of GBS bacteriuria had higher hemoglobin A1c values compared with diabetics without ASB (8.31±1.89 versus 7.31±1.84, p=0.0035). Our results demonstrate that gravidas with DM are at increased risk of ASB including GBS bacteriuria compared with non-diabetic gravidas.",
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Asymptomatic bacteriuria in pregestational diabetic pregnancies and the role of group B streptococcus. / Alvarez, Jesus R.; Fechner, Adam J.; Williams, Shauna; Ganesh, Vijaya L.; Apuzzio, Joseph.

In: American Journal of Perinatology, Vol. 27, No. 3, 04.03.2010, p. 231-234.

Research output: Contribution to journalArticle

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