Abstract
Nutrient metabolism is under circadian regulation. Disruption of circadian rhythms by lifestyle and behavioral choices such as work schedules, eating patterns, and social jetlag, seriously impacts metabolic homeostasis. Metabolic dysfunction due to chronic misalignment of an organism's endogenous rhythms is detrimental to health, increasing the risk of obesity, metabolic and cardiovascular disease, diabetes, and cancer. In this paper, we review literature on recent findings on the mechanisms that communicate metabolic signals to circadian clocks and vice versa, and how human behavioral changes imposed by societal and occupational demands affect the physiological networks integrating peripheral clocks and metabolism. Finally, we discuss factors possibly contributing to inter-individual variability in response to circadian changes in the context of metabolic (dys)function.
| Original language | English (US) |
|---|---|
| Article number | 132 |
| Journal | Frontiers in Nutrition |
| Volume | 6 |
| DOIs | |
| State | Published - Aug 28 2019 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Food Science
- Endocrinology, Diabetes and Metabolism
- Nutrition and Dietetics
Keywords
- chronodisruption
- circadian rhythms
- metabolic syndrome
- metabolism
- shift work
Cite this
}
At the Interface of Lifestyle, Behavior, and Circadian Rhythms : Metabolic Implications. / Bae, Seul A.; Fang, Ming Zhu; Rustgi, Vinod; Zarbl, Helmut; Androulakis, Ioannis P.
In: Frontiers in Nutrition, Vol. 6, 132, 28.08.2019.Research output: Contribution to journal › Review article
TY - JOUR
T1 - At the Interface of Lifestyle, Behavior, and Circadian Rhythms
T2 - Metabolic Implications
AU - Bae, Seul A.
AU - Fang, Ming Zhu
AU - Rustgi, Vinod
AU - Zarbl, Helmut
AU - Androulakis, Ioannis P.
PY - 2019/8/28
Y1 - 2019/8/28
N2 - Nutrient metabolism is under circadian regulation. Disruption of circadian rhythms by lifestyle and behavioral choices such as work schedules, eating patterns, and social jetlag, seriously impacts metabolic homeostasis. Metabolic dysfunction due to chronic misalignment of an organism's endogenous rhythms is detrimental to health, increasing the risk of obesity, metabolic and cardiovascular disease, diabetes, and cancer. In this paper, we review literature on recent findings on the mechanisms that communicate metabolic signals to circadian clocks and vice versa, and how human behavioral changes imposed by societal and occupational demands affect the physiological networks integrating peripheral clocks and metabolism. Finally, we discuss factors possibly contributing to inter-individual variability in response to circadian changes in the context of metabolic (dys)function.
AB - Nutrient metabolism is under circadian regulation. Disruption of circadian rhythms by lifestyle and behavioral choices such as work schedules, eating patterns, and social jetlag, seriously impacts metabolic homeostasis. Metabolic dysfunction due to chronic misalignment of an organism's endogenous rhythms is detrimental to health, increasing the risk of obesity, metabolic and cardiovascular disease, diabetes, and cancer. In this paper, we review literature on recent findings on the mechanisms that communicate metabolic signals to circadian clocks and vice versa, and how human behavioral changes imposed by societal and occupational demands affect the physiological networks integrating peripheral clocks and metabolism. Finally, we discuss factors possibly contributing to inter-individual variability in response to circadian changes in the context of metabolic (dys)function.
KW - chronodisruption
KW - circadian rhythms
KW - metabolic syndrome
KW - metabolism
KW - shift work
UR - http://www.scopus.com/inward/record.url?scp=85072732152&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85072732152&partnerID=8YFLogxK
U2 - 10.3389/fnut.2019.00132
DO - 10.3389/fnut.2019.00132
M3 - Review article
AN - SCOPUS:85072732152
VL - 6
JO - Frontiers in Nutrition
JF - Frontiers in Nutrition
SN - 2296-861X
M1 - 132
ER -