ATP-dependent proteases that also chaperone protein biogenesis

  • Carolyn K. Suzuki
  • , Martijn Rep
  • , Jan Maarten Van Dijl
  • , Kitaru Suda
  • , Leslie A. Grivell
  • , Gottfried Schatz

Research output: Contribution to journalReview articlepeer-review

214 Scopus citations

Abstract

The ATP-dependent proteases Clp and FtsH from bacteria, as well as mitochondrial homologs of FtsH and Lon from yeast, may act as chaperones; they mediate not only proteolysis, but also the insertion of proteins into membranes and the disassembly or oligomerization of protein complexes, The coordination of such processes with selective proteolysis may function in the quality control of protein biogenesis.

Original languageEnglish (US)
Pages (from-to)118-123
Number of pages6
JournalTrends in Biochemical Sciences
Volume22
Issue number4
DOIs
StatePublished - Apr 1997
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

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