Attomolar sensitive functional proteomic assay for biomarker detection and drug screening

M. Javanmard, J. Mok, M. Mindrinos, R. W. Davis

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Kinases are known to play important roles in cellular signaling, thus exhibiting tremendous potential as effective biomarkers. Here, we developed a multiplexed microfluidic assay capable of optically detecting kinase activity at concentrations as low as 10 attoMolar (7 active molecules=12×10 -24 moles) with a dynamic range of five orders of magnitude within one hour.

Original languageEnglish (US)
Title of host publication14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Pages974-976
Number of pages3
StatePublished - 2010
Externally publishedYes
Event14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen, Netherlands
Duration: Oct 3 2010Oct 7 2010

Publication series

Name14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Volume2

Other

Other14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Country/TerritoryNetherlands
CityGroningen
Period10/3/1010/7/10

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering

Keywords

  • Attomolar
  • Functional proteomic assay
  • Kinases
  • Magnetic beads
  • Microfluidics

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