Autism and oxidative stress: Evidence from an animal model

Michelle A. Cheh, Alycia K. Halladay, Carrie L. Yochum, Kenneth R. Reuhl, Marianne Polunas, Xue Ming, George C. Wagner

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Autism is a neurodevelopmental disorder with core symptoms of impaired social interactions, de cits in verbal and nonverbal communication, and the appearance of stereotypic and sometimes self-injurious behaviors. These symptoms appear early and persist throughout the life of the individual (Rapin, 1997). The intensity of symptom manifestation varies along a continuum with mild but pervasive developmental disturbances at one end of the spectrum to severely retarded and compromised individuals at the other end. Patients with Asperger syndrome are higher functioning autistic individuals with impaired social skills but less severe language de cits. Some autistic individuals manifest exceptional skills for restricted topics, but these savant skills are embedded in an otherwise restricted behavioral repertoire that only serves to heighten their occurrence by contrast.

Original languageEnglish (US)
Title of host publicationAutism
Subtitle of host publicationOxidative Stress, Inflammation, and Immune Abnormalities
PublisherCRC Press
Pages131-152
Number of pages22
ISBN (Electronic)9781420068870
ISBN (Print)9781420068818
StatePublished - Jan 1 2009

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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