Autologous Homologous Skin Constructs Allow Safe Closure of Wounds: A Retrospective, Noncontrolled, Multicentered Case Series

Gerhard S. Mundinger, Gerhard S. Mundinger, David G. Armstrong, David J. Smith, Alexander M. Sailon, Abhishek Chatterjee, Greg Tamagnini, Joanna Partridge, Nicholas Baetz, Pratima Labroo, Edward W. Swanson, Nikolai A. Sopko, Mark S. Granick

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

An autologous homologous skin construct (AHSC) has been developed for the repair and replacement of skin. It is created from a small, full-thickness harvest of healthy skin, which contains endogenous regenerative populations involved in native skin repair. A multicenter retrospective review of 15 wounds in 15 patients treated with AHSC was performed to evaluate the hypothesis that a single application could result in wound closure in a variety of wound types and that the resulting tissue would resemble native skin. Patients and wounds were selected and managed per provider's discretion with no predefined inclusion, exclusion, or follow-up criteria. Dressings were changed weekly. Graft take and wound closure were documented during follow-up visits and imaged with a digital camera. Wound etiologies included 5 acute and chronic burn, 4 acute traumatic, and 6 chronic wounds. All wounds were closed with a single application of AHSC manufactured from a single tissue harvest. Median wound, harvest, and defect-to-harvest size ratio were 120 cm2(range, 27-4800 cm2), 14 cm2(range, 3-20 cm2), and 11:1 (range, 2:1-343:1), respectively. No adverse reactions with the full-thickness harvest site or the AHSC treatment site were reported. Average follow-up was 4 ± 3 months. An AHSC-treated area was biopsied, and a micrograph of the area was developed using immunofluorescent confocal microscopy, which demonstrated mature, full-thickness skin with nascent hair follicles and glands. This early clinical experience with ASHC suggests that it can close different wound types; however, additional studies are needed to verify this statement.

Original languageEnglish (US)
Article numbere2840
JournalPlastic and Reconstructive Surgery - Global Open
DOIs
StateAccepted/In press - 2020

All Science Journal Classification (ASJC) codes

  • Surgery

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