Autophagy and the degradation of mitochondria

S. J. Goldman Scott J., Robert Taylor, Yong Zhang, Shengkan Jin

Research output: Contribution to journalReview articlepeer-review

106 Scopus citations

Abstract

The cellular process of macromolecular degradation known as macroautophagy has long been known to play a role in the elimination of mitochondria. Over the past decade, much progress has been made in the development of systems by which the nature and mechanism of mitochondria degradation may be studied. Recent findings imply that the degradation of mitochondria via autophagy may be more specific and more tightly regulated than originally thought, and have led to designation of this specific type of autophagy as " mitophagy" In this review we provide a brief history of the development of mitophagy models and their associated discoveries.

Original languageEnglish (US)
Pages (from-to)309-315
Number of pages7
JournalMitochondrion
Volume10
Issue number4
DOIs
StatePublished - Jun 2010

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Molecular Biology
  • Cell Biology

Keywords

  • Adipocyte
  • Autophagy
  • Mitochondria
  • Mitophagy
  • Reticulocyte

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