Autoshaping induces ethanol drinking in nondeprived rats: Evidence of long-term retention but no induction of ethanol preference

Arthur Tomie, Teresa Kuo, Khristine R. Apor, Kimberly E. Salomon, Larissa A. Pohorecky

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

The effects of autoshaping procedures (paired vs. random) and sipper fluid (ethanol vs. water) on sipper-directed drinking were evaluated in male Long-Evans rats maintained with free access to food and water. For the paired/ethanol group (n=16), autoshaping procedures consisted of presenting the ethanol sipper (containing 0% to 28% unsweetened ethanol) conditioned stimulus (CS) followed by the response-independent presentation of food unconditioned stimulus (US). The random/ethanol group (n=8) received the sipper CS and food US randomly with respect to one another. The paired/water group (n=8) received only water in the sipper CS. The paired/ethanol group showed higher grams per kilogram ethanol intake than the random/ethanol group did at ethanol concentrations of 8% to 28%. The paired/ethanol group showed higher sipper CS-directed milliliter fluid consumption than the paired/water group did at ethanol concentrations of 1% to 6%, and 15%, 16%, 18%, and 20%. Following a 42-day retention interval, the paired/ethanol group showed superior retention of CS-directed drinking of 18% ethanol, relative to the random/ethanol group, and superior retention of CS-directed milliliter fluid drinking relative to the paired/water group. When tested for home cage ethanol preference using limited access two-bottle (28% ethanol vs. water) procedures, the paired/ethanol and random/ethanol groups did not differ on any drinking measures.

Original languageEnglish (US)
Pages (from-to)797-804
Number of pages8
JournalPharmacology Biochemistry and Behavior
Volume77
Issue number4
DOIs
StatePublished - Apr 1 2004

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

Keywords

  • Autoshaping
  • Ethanol
  • Pavlovian
  • Preference
  • Pseudoconditioning
  • Rats
  • Retention

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