Axon patterning requires DN-cadherin, a novel neuronal adhesion receptor, in the drosophila embryonic CNS

Youichi Iwai, Tadao Usui, Shinji Hirano, Ruth Steward, Masatoshi Takeichi, Tadashi Uemura

Research output: Contribution to journalArticlepeer-review

241 Scopus citations

Abstract

We identified DN-cadherin, a novel Drosophila cadherin that is expressed in axons and in the mesoderm. Although DN-cadherin has diverged from vertebrate classic cadherins in terms of its extracellular structure, it still can form a complex with catenins and induce cell aggregation, as do the vertebrate molecules. Loss-of-function mutations of the gene resulted in either embryonic lethality or uncoordinated locomotion of adults. In the central nervous system of null mutant embryos, subsets of ipsilateral axons displayed a variety of aberrant trajectories including failure of position shifts, defective bundling, and errors in directional migration of growth cones. These results suggest that processes of axon patterning critically depend on DN-cadherin-mediated axon-axon interactions.

Original languageEnglish (US)
Pages (from-to)77-89
Number of pages13
JournalNeuron
Volume19
Issue number1
DOIs
StatePublished - Jul 1997

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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