Abstract
Human neural stem cells (hNSCs) cultured on graphene-nanoparticle hybrid structures show a unique behavior wherein the axons from the differentiating hNSCs show enhanced growth and alignment. We show that the axonal alignment is primarily due to the presence of graphene and the underlying nanoparticle monolayer causes enhanced neuronal differentiation of the hNSCs, thus having great implications of these hybrid-nanostructures for neuro-regenerative medicine.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5477-5482 |
| Number of pages | 6 |
| Journal | Advanced Materials |
| Volume | 25 |
| Issue number | 38 |
| DOIs | |
| State | Published - Jul 9 2013 |
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All Science Journal Classification (ASJC) codes
- Materials Science(all)
- Mechanics of Materials
- Mechanical Engineering
Keywords
- axonal alignment
- graphene-coated nanostructures
- neural stem cells
- stem cell differentiation
Cite this
}
Axonal alignment and enhanced neuronal differentiation of neural stem cells on graphene-nanoparticle hybrid structures. / Solanki, Aniruddh; Chueng, Sy Tsong Dean; Yin, Perry T.; Kappera, Rajesh; Chhowalla, Manishkumar; Lee, Ki.
In: Advanced Materials, Vol. 25, No. 38, 09.07.2013, p. 5477-5482.Research output: Contribution to journal › Article
TY - JOUR
T1 - Axonal alignment and enhanced neuronal differentiation of neural stem cells on graphene-nanoparticle hybrid structures
AU - Solanki, Aniruddh
AU - Chueng, Sy Tsong Dean
AU - Yin, Perry T.
AU - Kappera, Rajesh
AU - Chhowalla, Manishkumar
AU - Lee, Ki
PY - 2013/7/9
Y1 - 2013/7/9
N2 - Human neural stem cells (hNSCs) cultured on graphene-nanoparticle hybrid structures show a unique behavior wherein the axons from the differentiating hNSCs show enhanced growth and alignment. We show that the axonal alignment is primarily due to the presence of graphene and the underlying nanoparticle monolayer causes enhanced neuronal differentiation of the hNSCs, thus having great implications of these hybrid-nanostructures for neuro-regenerative medicine.
AB - Human neural stem cells (hNSCs) cultured on graphene-nanoparticle hybrid structures show a unique behavior wherein the axons from the differentiating hNSCs show enhanced growth and alignment. We show that the axonal alignment is primarily due to the presence of graphene and the underlying nanoparticle monolayer causes enhanced neuronal differentiation of the hNSCs, thus having great implications of these hybrid-nanostructures for neuro-regenerative medicine.
KW - axonal alignment
KW - graphene-coated nanostructures
KW - neural stem cells
KW - stem cell differentiation
UR - http://www.scopus.com/inward/record.url?scp=84885862560&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84885862560&partnerID=8YFLogxK
U2 - 10.1002/adma.201302219
DO - 10.1002/adma.201302219
M3 - Article
C2 - 23824715
AN - SCOPUS:84885862560
VL - 25
SP - 5477
EP - 5482
JO - Advanced Materials
JF - Advanced Materials
SN - 0935-9648
IS - 38
ER -