Axonal alignment and enhanced neuronal differentiation of neural stem cells on graphene-nanoparticle hybrid structures

Aniruddh Solanki, Sy Tsong Dean Chueng, Perry T. Yin, Rajesh Kappera, Manishkumar Chhowalla, Ki Lee

Research output: Contribution to journalArticle

122 Scopus citations

Abstract

Human neural stem cells (hNSCs) cultured on graphene-nanoparticle hybrid structures show a unique behavior wherein the axons from the differentiating hNSCs show enhanced growth and alignment. We show that the axonal alignment is primarily due to the presence of graphene and the underlying nanoparticle monolayer causes enhanced neuronal differentiation of the hNSCs, thus having great implications of these hybrid-nanostructures for neuro-regenerative medicine.

Original languageEnglish (US)
Pages (from-to)5477-5482
Number of pages6
JournalAdvanced Materials
Volume25
Issue number38
DOIs
StatePublished - Jul 9 2013

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Keywords

  • axonal alignment
  • graphene-coated nanostructures
  • neural stem cells
  • stem cell differentiation

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