Abstract
Human neural stem cells (hNSCs) cultured on graphene-nanoparticle hybrid structures show a unique behavior wherein the axons from the differentiating hNSCs show enhanced growth and alignment. We show that the axonal alignment is primarily due to the presence of graphene and the underlying nanoparticle monolayer causes enhanced neuronal differentiation of the hNSCs, thus having great implications of these hybrid-nanostructures for neuro-regenerative medicine.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5477-5482 |
| Number of pages | 6 |
| Journal | Advanced Materials |
| Volume | 25 |
| Issue number | 38 |
| DOIs | |
| State | Published - Jul 9 2013 |
All Science Journal Classification (ASJC) codes
- Materials Science(all)
- Mechanics of Materials
- Mechanical Engineering
Keywords
- axonal alignment
- graphene-coated nanostructures
- neural stem cells
- stem cell differentiation
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Cite this
Solanki, A., Chueng, S. T. D., Yin, P. T., Kappera, R., Chhowalla, M., & Lee, K. (2013). Axonal alignment and enhanced neuronal differentiation of neural stem cells on graphene-nanoparticle hybrid structures. Advanced Materials, 25(38), 5477-5482. https://doi.org/10.1002/adma.201302219