Axonal alignment and enhanced neuronal differentiation of neural stem cells on graphene-nanoparticle hybrid structures

Aniruddh Solanki; Sy Tsong Dean Chueng; Perry T. Yin; Rajesh Kappera; Manish Chhowalla; Ki Bum Lee

doi:10.1002/adma.201302219

Axonal alignment and enhanced neuronal differentiation of neural stem cells on graphene-nanoparticle hybrid structures

Aniruddh Solanki, Sy Tsong Dean Chueng, Perry T. Yin, Rajesh Kappera, Manish Chhowalla, Ki Bum Lee

Research output: Contribution to journal › Article › peer-review

195 Scopus citations

Abstract

Human neural stem cells (hNSCs) cultured on graphene-nanoparticle hybrid structures show a unique behavior wherein the axons from the differentiating hNSCs show enhanced growth and alignment. We show that the axonal alignment is primarily due to the presence of graphene and the underlying nanoparticle monolayer causes enhanced neuronal differentiation of the hNSCs, thus having great implications of these hybrid-nanostructures for neuro-regenerative medicine.

Original language	English (US)
Pages (from-to)	5477-5482
Number of pages	6
Journal	Advanced Materials
Volume	25
Issue number	38
DOIs	https://doi.org/10.1002/adma.201302219
State	Published - Oct 11 2013

All Science Journal Classification (ASJC) codes

General Materials Science
Mechanics of Materials
Mechanical Engineering

Keywords

axonal alignment
graphene-coated nanostructures
neural stem cells
stem cell differentiation

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10.1002/adma.201302219

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abstract = "Human neural stem cells (hNSCs) cultured on graphene-nanoparticle hybrid structures show a unique behavior wherein the axons from the differentiating hNSCs show enhanced growth and alignment. We show that the axonal alignment is primarily due to the presence of graphene and the underlying nanoparticle monolayer causes enhanced neuronal differentiation of the hNSCs, thus having great implications of these hybrid-nanostructures for neuro-regenerative medicine.",

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author = "Aniruddh Solanki and Chueng, {Sy Tsong Dean} and Yin, {Perry T.} and Rajesh Kappera and Manish Chhowalla and Lee, {Ki Bum}",

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AU - Solanki, Aniruddh

AU - Chueng, Sy Tsong Dean

AU - Yin, Perry T.

AU - Kappera, Rajesh

AU - Chhowalla, Manish

AU - Lee, Ki Bum

PY - 2013/10/11

Y1 - 2013/10/11

N2 - Human neural stem cells (hNSCs) cultured on graphene-nanoparticle hybrid structures show a unique behavior wherein the axons from the differentiating hNSCs show enhanced growth and alignment. We show that the axonal alignment is primarily due to the presence of graphene and the underlying nanoparticle monolayer causes enhanced neuronal differentiation of the hNSCs, thus having great implications of these hybrid-nanostructures for neuro-regenerative medicine.

AB - Human neural stem cells (hNSCs) cultured on graphene-nanoparticle hybrid structures show a unique behavior wherein the axons from the differentiating hNSCs show enhanced growth and alignment. We show that the axonal alignment is primarily due to the presence of graphene and the underlying nanoparticle monolayer causes enhanced neuronal differentiation of the hNSCs, thus having great implications of these hybrid-nanostructures for neuro-regenerative medicine.

KW - axonal alignment

KW - graphene-coated nanostructures

KW - neural stem cells

KW - stem cell differentiation

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JO - Advanced Materials

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Axonal alignment and enhanced neuronal differentiation of neural stem cells on graphene-nanoparticle hybrid structures

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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