Axonal autophagosomes use the ride-on service for retrograde transport toward the soma

Xiu Tang Cheng, Bing Zhou, Mei Yao Lin, Qian Cai, Zu Hang Sheng

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Degradation of autophagic vacuoles (AVs) via lysosomes is an important homeostatic process in cells. Neurons are highly polarized cells with long axons, thus facing special challenges to transport AVs generated at distal processes toward the soma where mature acidic lysosomes are relatively enriched. We recently revealed a new motor-adaptor sharing mechanism driving autophagosome transport to the soma. Late endosome (LE)-loaded dynein-SNAPIN motoradaptor complexes mediate the retrograde transport of autophagosomes upon their fusion with LEs in distal axons. This motor-adaptor sharing mechanism enables neurons to maintain effective autophagic clearance in the soma, thus reducing autophagic stress in axons. Therefore, our study reveals a new cellular mechanism underlying the removal of distal AVs engulfing aggregated misfolded proteins and dysfunctional organelles associated with several major neurodegenerative diseases.

Original languageEnglish (US)
Pages (from-to)1434-1436
Number of pages3
JournalAutophagy
Volume11
Issue number8
DOIs
StatePublished - Jan 1 2015

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

Keywords

  • Amphisome
  • Autophagic clearance
  • Autophagosome
  • Autophagy
  • Axon
  • Dynein
  • Late endosome
  • Lysosome
  • Retrograde transport
  • SNAPIN
  • Syntaxin 17

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