B lymphocyte cytokine profile in a monozygotic twin pair discordant for nephrotic syndrome

Anibal Valentin-Acevedo, Lori Ruth Covey, Sevgi Gurkan

Research output: Contribution to journalArticlepeer-review

Abstract

Nephrotic syndrome (NS) is the most common glomerular disorder of childhood and a leading cause of pediatric renal failure; however the etiology of NS remains largely unknown. Recent reports demonstrating that an anti- CD20 antibody can induce remission of NS strongly suggest a potentially novel role for B cells in NS pathogenesis. In this report, the authors investigated B cell cytokine profiles following in vitro stimulation in a monozygotic twin pair discordant for NS. The results revealed that clear differences in the cytokine profiles of B cells exist between the patient and the unaffected twin. This is the first report of altered B lymphocyte responses among a monozygotic twin pair that is discordant for NS. Future studies are needed to identify cytokine differences that track with NS relapse and/or NS response to therapy.

Original languageEnglish (US)
Pages (from-to)875-877
Number of pages3
JournalIndian Journal of Pediatrics
Volume80
Issue number10
DOIs
StatePublished - Oct 2013

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Keywords

  • B lymphocytes
  • Monozygotic twin
  • Nephrotic syndrome
  • Pediatric

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