@article{e44c9df747804609b7edca09a2388f53,
title = "BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function",
abstract = "BRCA1 interacts in vivo with a novel protein, BACH1, a member of the DEAH helicase family. BACH1 binds directly to the BRCT repeats of BRCA1. A BACH1 derivative, bearing a mutation in a residue that was essential for catalytic function in other helicases, interfered with normal double-strand break repair in a manner that was dependent on its BRCA1 binding function. Thus, BACH1/BRCA1 complex formation contributes to a key BRCA1 activity. In addition, germline BACH1 mutations affecting the helicase domain were detected in two early-onset breast cancer patients and not in 200 matched controls. Thus, it is conceivable that, like BRCA1, BACH1 is a target of germline cancer-inducing mutations.",
author = "Cantor, {Sharon B.} and Bell, {Daphne W.} and Shridar Ganesan and Kass, {Elizabeth M.} and Ronny Drapkin and Steven Grossman and Wahrer, {Doke C.R.} and Sgroi, {Dennis C.} and Lane, {William S.} and Haber, {Daniel A.} and Livingston, {David M.}",
note = "Funding Information: We are particularly grateful to all of our laboratory colleagues for helpful advice and discussions. We also wish to thank Jim DeCaprio for the preparation of BACH1 antibodies, Ralph Scully for the BRCA1 reconstituted HCC1937 cells, and Kerry Pierce for expert HPLC and mass spectrometry analysis. We also thank Junjie Chen for providing the BARD1 antibody. This work was supported by grants from the National Cancer Institute to D. M. L. and S. C. as well as a grant from the Dana Farber-Partners Gillette Women's Cancer Program and the Dana Farber/Harvard Specialized Program of Research Excellence (SPORE) in breast cancer from the National Cancer Institute (P50 CA89393). S. G. is a recipient of a Howard Hughes Medical Institute postdoctoral fellowship for physicians. R. D. is funded by NIH training grant T32 HL07627-16. ",
year = "2001",
month = apr,
day = "6",
doi = "10.1016/S0092-8674(01)00304-X",
language = "English (US)",
volume = "105",
pages = "149--160",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "1",
}