The rationale for a degradable bioactive glass coating is to lead the bone to appose gradually to the metal. A bioactive glass already described in the literature (bg A) and a sodium-calcium-silicate non-bioactive glass sprayed as a control were studied. Young adult New Zealand White rabbits were selected as animal model. A hole was drilled from the femural intercondylar groove and Ti6Al4V-coated cylinders were implanted. Retrieval took place at 1, 2, 4, 6, 8 and 10 months and samples were analyzed by backscattered electron microscopy (BSEM). For all the samples of bioactive glass, bone was in tight apposition with the coating. As time progressed, bone showed characters of physiological remodelling (newly formed bone substituting areas of bone resorption) close to the coating. At the interface between bone and bioactive glass coating, the apposition was so tight that it was not possible to discern a clear demarcation, even at higher BSEM magnification. A second key feature, in the behavior of the bioactive glass coatings invivo, was the gradual degradation and the eventual apposition of bone directly to Ti6Al4V.
All Science Journal Classification (ASJC) codes
- Orthopedics and Sports Medicine