Bacteriophage φ80-induced low molecular weight RNA

George Pieczenik, B. G. Barrell, Malcolm L. Gefter

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


A species of low molecular weight RNA (M3) which is produced in bacteriophage φ80-infected Escherichia coli has been isolated and characterized. M3 appears immediately after infection and its synthesis continues until lysis. This RNA is unstable; its mean half-life is 13.5 min. The structural gene for M3 is localized on the φ80 genome to the right of the exonuclease locus and to the left of gene Q. The complete nucleotide sequence of M3 has been determined. It is 62 nucleotides in length. The 5′ end begins with pppGp and the 3′ terminus is C-U-U-U-U-U-A-AOH. The sequence and sensitivity to ribonuclease digestion suggests a highly double-stranded structure for M3.

Original languageEnglish (US)
Pages (from-to)152-165
Number of pages14
JournalArchives of Biochemistry and Biophysics
Issue number1
StatePublished - Sep 1972
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology


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