Barrett's esophagus: Cancer and molecular biology

Michael K. Gibson, Arashinder S. Dhaliwal, Nicholas J. Clemons, Wayne A. Phillips, Katerina Dvorak, Daniel Tong, Simon Law, E. Daniel Pirchi, Jari Räsänen, Mark J. Krasna, Kaushal Parikh, Kausilia K. Krishnadath, Yu Chen, Leonard Griffiths, Benjamin J. Colleypriest, J. Mark Farrant, David Tosh, Kiron M. Das, Manisha Bajpai

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The following paper on the molecular biology of Barrett's esophagus (BE) includes commentaries on signaling pathways central to the development of BE including Hh, NF-κB, and IL-6/STAT3; surgical approaches for esophagectomy and classification of lesions by appropriate therapy; the debate over the merits of minimally invasive esophagectomy versus open surgery; outcomes for patients with pharyngolaryngoesophagectomy; the applications of neoadjuvant chemotherapy and chemoradiotherapy; animal models examining the surgical models of BE and esophageal adenocarcinoma; the roles of various morphogens and Cdx2 in BE; and the use of in vitro BE models for chemoprevention studies.

Original languageEnglish (US)
Pages (from-to)296-314
Number of pages19
JournalAnnals of the New York Academy of Sciences
Volume1300
Issue number1
DOIs
StatePublished - Jan 1 2013

Fingerprint

Molecular biology
Barrett Esophagus
Esophageal Neoplasms
Molecular Biology
Chemoradiotherapy
Esophagectomy
Chemotherapy
Surgery
Interleukin-6
Animals
Anatomic Models
Chemoprevention
Adenocarcinoma
Animal Models
Cancer
Drug Therapy
Animal Model
Pathway
Therapy
Merit

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Keywords

  • Barrett's esophagus
  • Esophageal adenocarcinoma
  • Esophagectomy
  • MIE

Cite this

Gibson, M. K., Dhaliwal, A. S., Clemons, N. J., Phillips, W. A., Dvorak, K., Tong, D., ... Bajpai, M. (2013). Barrett's esophagus: Cancer and molecular biology. Annals of the New York Academy of Sciences, 1300(1), 296-314. https://doi.org/10.1111/nyas.12252
Gibson, Michael K. ; Dhaliwal, Arashinder S. ; Clemons, Nicholas J. ; Phillips, Wayne A. ; Dvorak, Katerina ; Tong, Daniel ; Law, Simon ; Pirchi, E. Daniel ; Räsänen, Jari ; Krasna, Mark J. ; Parikh, Kaushal ; Krishnadath, Kausilia K. ; Chen, Yu ; Griffiths, Leonard ; Colleypriest, Benjamin J. ; Farrant, J. Mark ; Tosh, David ; Das, Kiron M. ; Bajpai, Manisha. / Barrett's esophagus : Cancer and molecular biology. In: Annals of the New York Academy of Sciences. 2013 ; Vol. 1300, No. 1. pp. 296-314.
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Gibson, MK, Dhaliwal, AS, Clemons, NJ, Phillips, WA, Dvorak, K, Tong, D, Law, S, Pirchi, ED, Räsänen, J, Krasna, MJ, Parikh, K, Krishnadath, KK, Chen, Y, Griffiths, L, Colleypriest, BJ, Farrant, JM, Tosh, D, Das, KM & Bajpai, M 2013, 'Barrett's esophagus: Cancer and molecular biology', Annals of the New York Academy of Sciences, vol. 1300, no. 1, pp. 296-314. https://doi.org/10.1111/nyas.12252

Barrett's esophagus : Cancer and molecular biology. / Gibson, Michael K.; Dhaliwal, Arashinder S.; Clemons, Nicholas J.; Phillips, Wayne A.; Dvorak, Katerina; Tong, Daniel; Law, Simon; Pirchi, E. Daniel; Räsänen, Jari; Krasna, Mark J.; Parikh, Kaushal; Krishnadath, Kausilia K.; Chen, Yu; Griffiths, Leonard; Colleypriest, Benjamin J.; Farrant, J. Mark; Tosh, David; Das, Kiron M.; Bajpai, Manisha.

In: Annals of the New York Academy of Sciences, Vol. 1300, No. 1, 01.01.2013, p. 296-314.

Research output: Contribution to journalArticle

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AU - Law, Simon

AU - Pirchi, E. Daniel

AU - Räsänen, Jari

AU - Krasna, Mark J.

AU - Parikh, Kaushal

AU - Krishnadath, Kausilia K.

AU - Chen, Yu

AU - Griffiths, Leonard

AU - Colleypriest, Benjamin J.

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Gibson MK, Dhaliwal AS, Clemons NJ, Phillips WA, Dvorak K, Tong D et al. Barrett's esophagus: Cancer and molecular biology. Annals of the New York Academy of Sciences. 2013 Jan 1;1300(1):296-314. https://doi.org/10.1111/nyas.12252