Basal forebrain microinjections of L-3,3′,5-triiodothyronine modify sleep in hypothyroid rats

Shi Qing Zhang, Joseph V. Martin

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Male rats were injected bilaterally with various doses of L-3,3′,5-triiodothyronine (T3) into basal forebrain areas. The electroencephalogram (EEG), electromyogram (EMG) and brain temperature (Tbr) were then measured in 8-h studies. In the medial preoptic area (MPA), a 4 μg dose of T3 caused significant elevations in REM sleep as compared to control injections. In the median preoptic nucleus (MnPO), both 2 and 4 μg doses of T3 significantly inhibited non-REM sleep. Injections to the diagonal band of Broca did not alter EEG-defined sleep. Influences on Tbr were not significant for any of the treatments. Since these effects of T3 were demonstrated after acute injections, the data are consistent with possible non-genomic actions of thyroid hormones in adult brain.

Original languageEnglish (US)
Pages (from-to)271-272
Number of pages2
JournalPsychiatry and Clinical Neurosciences
Volume55
Issue number3
DOIs
StatePublished - Jul 7 2001

Fingerprint

Microinjections
Triiodothyronine
Sleep
Preoptic Area
Injections
Electroencephalography
Diagonal Band of Broca
REM Sleep
Brain
Electromyography
Thyroid Hormones
Temperature
Basal Forebrain
Therapeutics

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health

Keywords

  • Basal forebrain
  • Non-genomic
  • Preoptic area
  • Sleep
  • Thyroid hormone
  • Triiodothyronine

Cite this

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abstract = "Male rats were injected bilaterally with various doses of L-3,3′,5-triiodothyronine (T3) into basal forebrain areas. The electroencephalogram (EEG), electromyogram (EMG) and brain temperature (Tbr) were then measured in 8-h studies. In the medial preoptic area (MPA), a 4 μg dose of T3 caused significant elevations in REM sleep as compared to control injections. In the median preoptic nucleus (MnPO), both 2 and 4 μg doses of T3 significantly inhibited non-REM sleep. Injections to the diagonal band of Broca did not alter EEG-defined sleep. Influences on Tbr were not significant for any of the treatments. Since these effects of T3 were demonstrated after acute injections, the data are consistent with possible non-genomic actions of thyroid hormones in adult brain.",
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Basal forebrain microinjections of L-3,3′,5-triiodothyronine modify sleep in hypothyroid rats. / Zhang, Shi Qing; Martin, Joseph V.

In: Psychiatry and Clinical Neurosciences, Vol. 55, No. 3, 07.07.2001, p. 271-272.

Research output: Contribution to journalArticle

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AU - Martin, Joseph V.

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