Basal forebrain microinjections of L-3,3′,5-triiodothyronine modify sleep in hypothyroid rats

Shi Qing Zhang, Joseph V. Martin

Research output: Contribution to journalArticle

2 Scopus citations


Male rats were injected bilaterally with various doses of L-3,3′,5-triiodothyronine (T3) into basal forebrain areas. The electroencephalogram (EEG), electromyogram (EMG) and brain temperature (Tbr) were then measured in 8-h studies. In the medial preoptic area (MPA), a 4 μg dose of T3 caused significant elevations in REM sleep as compared to control injections. In the median preoptic nucleus (MnPO), both 2 and 4 μg doses of T3 significantly inhibited non-REM sleep. Injections to the diagonal band of Broca did not alter EEG-defined sleep. Influences on Tbr were not significant for any of the treatments. Since these effects of T3 were demonstrated after acute injections, the data are consistent with possible non-genomic actions of thyroid hormones in adult brain.

Original languageEnglish (US)
Pages (from-to)271-272
Number of pages2
JournalPsychiatry and Clinical Neurosciences
Issue number3
StatePublished - Jul 7 2001

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health


  • Basal forebrain
  • Non-genomic
  • Preoptic area
  • Sleep
  • Thyroid hormone
  • Triiodothyronine

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