Abstract
Male rats were injected bilaterally with various doses of L-3,3′,5-triiodothyronine (T3) into basal forebrain areas. The electroencephalogram (EEG), electromyogram (EMG) and brain temperature (Tbr) were then measured in 8-h studies. In the medial preoptic area (MPA), a 4 μg dose of T3 caused significant elevations in REM sleep as compared to control injections. In the median preoptic nucleus (MnPO), both 2 and 4 μg doses of T3 significantly inhibited non-REM sleep. Injections to the diagonal band of Broca did not alter EEG-defined sleep. Influences on Tbr were not significant for any of the treatments. Since these effects of T3 were demonstrated after acute injections, the data are consistent with possible non-genomic actions of thyroid hormones in adult brain.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 271-272 |
| Number of pages | 2 |
| Journal | Psychiatry and Clinical Neurosciences |
| Volume | 55 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jul 7 2001 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Neuroscience(all)
- Neurology
- Clinical Neurology
- Psychiatry and Mental health
Keywords
- Basal forebrain
- Non-genomic
- Preoptic area
- Sleep
- Thyroid hormone
- Triiodothyronine
Cite this
}
Basal forebrain microinjections of L-3,3′,5-triiodothyronine modify sleep in hypothyroid rats. / Zhang, Shi Qing; Martin, Joseph V.
In: Psychiatry and Clinical Neurosciences, Vol. 55, No. 3, 07.07.2001, p. 271-272.Research output: Contribution to journal › Article
TY - JOUR
T1 - Basal forebrain microinjections of L-3,3′,5-triiodothyronine modify sleep in hypothyroid rats
AU - Zhang, Shi Qing
AU - Martin, Joseph V.
PY - 2001/7/7
Y1 - 2001/7/7
N2 - Male rats were injected bilaterally with various doses of L-3,3′,5-triiodothyronine (T3) into basal forebrain areas. The electroencephalogram (EEG), electromyogram (EMG) and brain temperature (Tbr) were then measured in 8-h studies. In the medial preoptic area (MPA), a 4 μg dose of T3 caused significant elevations in REM sleep as compared to control injections. In the median preoptic nucleus (MnPO), both 2 and 4 μg doses of T3 significantly inhibited non-REM sleep. Injections to the diagonal band of Broca did not alter EEG-defined sleep. Influences on Tbr were not significant for any of the treatments. Since these effects of T3 were demonstrated after acute injections, the data are consistent with possible non-genomic actions of thyroid hormones in adult brain.
AB - Male rats were injected bilaterally with various doses of L-3,3′,5-triiodothyronine (T3) into basal forebrain areas. The electroencephalogram (EEG), electromyogram (EMG) and brain temperature (Tbr) were then measured in 8-h studies. In the medial preoptic area (MPA), a 4 μg dose of T3 caused significant elevations in REM sleep as compared to control injections. In the median preoptic nucleus (MnPO), both 2 and 4 μg doses of T3 significantly inhibited non-REM sleep. Injections to the diagonal band of Broca did not alter EEG-defined sleep. Influences on Tbr were not significant for any of the treatments. Since these effects of T3 were demonstrated after acute injections, the data are consistent with possible non-genomic actions of thyroid hormones in adult brain.
KW - Basal forebrain
KW - Non-genomic
KW - Preoptic area
KW - Sleep
KW - Thyroid hormone
KW - Triiodothyronine
UR - http://www.scopus.com/inward/record.url?scp=0034983123&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034983123&partnerID=8YFLogxK
U2 - 10.1046/j.1440-1819.2001.00855.x
DO - 10.1046/j.1440-1819.2001.00855.x
M3 - Article
C2 - 11422871
AN - SCOPUS:0034983123
VL - 55
SP - 271
EP - 272
JO - Psychiatry and Clinical Neurosciences
JF - Psychiatry and Clinical Neurosciences
SN - 1323-1316
IS - 3
ER -