Abstract
Male rats were injected bilaterally with various doses of L-3,3′,5-triiodothyronine (T3) into basal forebrain areas. The electroencephalogram (EEG), electromyogram (EMG) and brain temperature (Tbr) were then measured in 8-h studies. In the medial preoptic area (MPA), a 4 μg dose of T3 caused significant elevations in REM sleep as compared to control injections. In the median preoptic nucleus (MnPO), both 2 and 4 μg doses of T3 significantly inhibited non-REM sleep. Injections to the diagonal band of Broca did not alter EEG-defined sleep. Influences on Tbr were not significant for any of the treatments. Since these effects of T3 were demonstrated after acute injections, the data are consistent with possible non-genomic actions of thyroid hormones in adult brain.
Original language | English (US) |
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Pages (from-to) | 271-272 |
Number of pages | 2 |
Journal | Psychiatry and Clinical Neurosciences |
Volume | 55 |
Issue number | 3 |
DOIs | |
State | Published - 2001 |
All Science Journal Classification (ASJC) codes
- General Neuroscience
- Neurology
- Clinical Neurology
- Psychiatry and Mental health
Keywords
- Basal forebrain
- Non-genomic
- Preoptic area
- Sleep
- Thyroid hormone
- Triiodothyronine