Bathymodiolamides A and B, ceramide derivatives from a deep-sea hydrothermal vent invertebrate mussel, bathymodiolus thermophilus

Eric H. Andrianasolo, Liti Haramaty, Kerry L. McPhail, Eileen White, Costantino Vetriani, Paul Falkowski, Richard Lutz

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Two ceramide derivatives, bathymodiolamides A (1) and B (2), were isolated from the deep-sea hydrothermal vent invertebrate mussel Bathymodiolus thermophilus. The molecular structures of these compounds were determined using a combination of NMR spectroscopy, mass spectrometry, and chemical degradation. Biological activities were assessed in a ApopScreen cell-based screen for apoptosis induction and potential anticancer activity. To our knowledge, this is the first report of secondary metabolites from the marine hydrothermal vent mussel B. thermophilus.

Original languageEnglish (US)
Pages (from-to)842-846
Number of pages5
JournalJournal of Natural Products
Volume74
Issue number4
DOIs
StatePublished - Apr 25 2011

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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