Behavioral and electroencephalographic effects of the adenosine1 agonist, L-PIA

Joseph V. Martin; Karen Faith Berman; Phil Skolnick; Wallace B. Mendelson

doi:10.1016/0091-3057(89)90549-2

Behavioral and electroencephalographic effects of the adenosine₁ agonist, L-PIA

Joseph V. Martin, Karen Faith Berman, Phil Skolnick, Wallace B. Mendelson

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The effects of N⁶-(L-2-phenylisopropyl)-adenosine (L-PIA), an A₁ agonist, were measured on both spontaneous locomotor activity and electroencephalographic (EEG) measures of sleep in rats. L-PIA strongly inhibited motor activity at 100 μg/kg intraperitoneally (IP), a dose which had no statistically significant effects on EEG-defined sleep. A higher dose of L-PIA (200 μg/kg) increased the latency to sleep initiation and inhibited later REM sleep. These results demonstrate that L-PIA can produce a state of apparent behavioral quiescence in the presence of EEG-defined arousal.

Original language	English (US)
Pages (from-to)	507-510
Number of pages	4
Journal	Pharmacology, Biochemistry and Behavior
Volume	34
Issue number	3
DOIs	https://doi.org/10.1016/0091-3057(89)90549-2
State	Published - Nov 1989

All Science Journal Classification (ASJC) codes

Biochemistry
Toxicology
Pharmacology
Clinical Biochemistry
Biological Psychiatry
Behavioral Neuroscience

Keywords

Adenosine agonist
Electroencephalogram
Locomotor activity
N-(L-2-phenylisopropyl)-adenosine (L-PIA)
REM
Sedation
Sleep

Access to Document

10.1016/0091-3057(89)90549-2

Cite this

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title = "Behavioral and electroencephalographic effects of the adenosine1 agonist, L-PIA",

abstract = "The effects of N6-(L-2-phenylisopropyl)-adenosine (L-PIA), an A1 agonist, were measured on both spontaneous locomotor activity and electroencephalographic (EEG) measures of sleep in rats. L-PIA strongly inhibited motor activity at 100 μg/kg intraperitoneally (IP), a dose which had no statistically significant effects on EEG-defined sleep. A higher dose of L-PIA (200 μg/kg) increased the latency to sleep initiation and inhibited later REM sleep. These results demonstrate that L-PIA can produce a state of apparent behavioral quiescence in the presence of EEG-defined arousal.",

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AU - Martin, Joseph V.

AU - Berman, Karen Faith

AU - Skolnick, Phil

AU - Mendelson, Wallace B.

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AB - The effects of N6-(L-2-phenylisopropyl)-adenosine (L-PIA), an A1 agonist, were measured on both spontaneous locomotor activity and electroencephalographic (EEG) measures of sleep in rats. L-PIA strongly inhibited motor activity at 100 μg/kg intraperitoneally (IP), a dose which had no statistically significant effects on EEG-defined sleep. A higher dose of L-PIA (200 μg/kg) increased the latency to sleep initiation and inhibited later REM sleep. These results demonstrate that L-PIA can produce a state of apparent behavioral quiescence in the presence of EEG-defined arousal.

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KW - N-(L-2-phenylisopropyl)-adenosine (L-PIA)

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