Behavioral and electroencephalographic effects of the adenosine1 agonist, L-PIA

Joseph V. Martin, Karen Faith Berman, Phil Skolnick, Wallace B. Mendelson

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


The effects of N6-(L-2-phenylisopropyl)-adenosine (L-PIA), an A1 agonist, were measured on both spontaneous locomotor activity and electroencephalographic (EEG) measures of sleep in rats. L-PIA strongly inhibited motor activity at 100 μg/kg intraperitoneally (IP), a dose which had no statistically significant effects on EEG-defined sleep. A higher dose of L-PIA (200 μg/kg) increased the latency to sleep initiation and inhibited later REM sleep. These results demonstrate that L-PIA can produce a state of apparent behavioral quiescence in the presence of EEG-defined arousal.

Original languageEnglish (US)
Pages (from-to)507-510
Number of pages4
JournalPharmacology, Biochemistry and Behavior
Issue number3
StatePublished - Nov 1989

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience


  • Adenosine agonist
  • Electroencephalogram
  • Locomotor activity
  • N-(L-2-phenylisopropyl)-adenosine (L-PIA)
  • REM
  • Sedation
  • Sleep


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