Behavioral inflexibility across two neurogenetic conditions: Down syndrome and fragile x syndrome

Clare Harrop; Aaron R. Dallman; Luc Lecavalier; James W. Bodfish; Brian A. Boyd

doi:10.1352/1944-7558-126.5.409

Behavioral inflexibility across two neurogenetic conditions: Down syndrome and fragile x syndrome

Clare Harrop, Aaron R. Dallman, Luc Lecavalier, James W. Bodfish, Brian A. Boyd

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Behavioral inflexibility (BI) has been highlighted to occur across genetic and neurodevelopmental disorders. This study characterized BI in two common neurogenetic conditions: Fragile X syndrome (FXS) and Down syndrome (DS). Caregivers of children with FXS (N ¼ 56; with ASD ¼ 28; FXS only ¼ 28) and DS (N ¼ 146) completed the Behavioral Inflexibility Scale (BIS) via an online survey. Total BIS scores were higher in FXSþASD than both FXS only and DS (p,.001). Most endorsed items were similar across the three groups, but scores were higher in the FXSþASD group. In all groups, BI associated with other clinical variables (receptive behaviors, anxiety, social communication). The current data suggest that BI is variable across neurogenetic conditions and higher in individuals with comorbid ASD.

Original language	English (US)
Pages (from-to)	409-420
Number of pages	12
Journal	American Journal on Intellectual and Developmental Disabilities
Volume	126
Issue number	5
DOIs	https://doi.org/10.1352/1944-7558-126.5.409
State	Published - 2020
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Medicine

Keywords

Behavioral inflexibility
Down syndrome
Fragile x syndrome

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10.1352/1944-7558-126.5.409

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title = "Behavioral inflexibility across two neurogenetic conditions: Down syndrome and fragile x syndrome",

abstract = "Behavioral inflexibility (BI) has been highlighted to occur across genetic and neurodevelopmental disorders. This study characterized BI in two common neurogenetic conditions: Fragile X syndrome (FXS) and Down syndrome (DS). Caregivers of children with FXS (N ¼ 56; with ASD ¼ 28; FXS only ¼ 28) and DS (N ¼ 146) completed the Behavioral Inflexibility Scale (BIS) via an online survey. Total BIS scores were higher in FXS{\th}ASD than both FXS only and DS (p,.001). Most endorsed items were similar across the three groups, but scores were higher in the FXS{\th}ASD group. In all groups, BI associated with other clinical variables (receptive behaviors, anxiety, social communication). The current data suggest that BI is variable across neurogenetic conditions and higher in individuals with comorbid ASD.",

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AU - Harrop, Clare

AU - Dallman, Aaron R.

AU - Lecavalier, Luc

AU - Bodfish, James W.

AU - Boyd, Brian A.

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PY - 2020

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N2 - Behavioral inflexibility (BI) has been highlighted to occur across genetic and neurodevelopmental disorders. This study characterized BI in two common neurogenetic conditions: Fragile X syndrome (FXS) and Down syndrome (DS). Caregivers of children with FXS (N ¼ 56; with ASD ¼ 28; FXS only ¼ 28) and DS (N ¼ 146) completed the Behavioral Inflexibility Scale (BIS) via an online survey. Total BIS scores were higher in FXSþASD than both FXS only and DS (p,.001). Most endorsed items were similar across the three groups, but scores were higher in the FXSþASD group. In all groups, BI associated with other clinical variables (receptive behaviors, anxiety, social communication). The current data suggest that BI is variable across neurogenetic conditions and higher in individuals with comorbid ASD.

AB - Behavioral inflexibility (BI) has been highlighted to occur across genetic and neurodevelopmental disorders. This study characterized BI in two common neurogenetic conditions: Fragile X syndrome (FXS) and Down syndrome (DS). Caregivers of children with FXS (N ¼ 56; with ASD ¼ 28; FXS only ¼ 28) and DS (N ¼ 146) completed the Behavioral Inflexibility Scale (BIS) via an online survey. Total BIS scores were higher in FXSþASD than both FXS only and DS (p,.001). Most endorsed items were similar across the three groups, but scores were higher in the FXSþASD group. In all groups, BI associated with other clinical variables (receptive behaviors, anxiety, social communication). The current data suggest that BI is variable across neurogenetic conditions and higher in individuals with comorbid ASD.

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Behavioral inflexibility across two neurogenetic conditions: Down syndrome and fragile x syndrome

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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