Behavioral time scale synaptic plasticity underlies CA1 place fields

Katie C. Bittner, Aaron D. Milstein, Christine Grienberger, Sandro Romani, Jeffrey C. Magee

Research output: Contribution to journalArticlepeer-review

147 Scopus citations

Abstract

Learning is primarily mediated by activity-dependent modifications of synaptic strength within neuronal circuits. We discovered that place fields in hippocampal area CA1 are produced by a synaptic potentiation notably different from Hebbian plasticity. Place fields could be produced in vivo in a single trial by potentiation of input that arrived seconds before and after complex spiking. The potentiated synaptic input was not initially coincident with action potentials or depolarization. This rule, named behavioral timescale synaptic plasticity, abruptly modifies inputs that were neither causal nor close in time to postsynaptic activation. In slices, five pairings of subthreshold presynaptic activity and calcium (Ca2+) plateau potentials produced a large potentiation with an asymmetric seconds-long time course. This plasticity efficiently stores entire behavioral sequences within synaptic weights to produce predictive place cell activity.

Original languageEnglish (US)
Pages (from-to)1033-1036
Number of pages4
JournalScience
Volume357
Issue number6355
DOIs
StatePublished - Sep 8 2017
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General

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