Benign gynecologic conditions are associated with ovarian cancer risk in African-American women: a case-control study

Hyo K. Park, Joellen M. Schildkraut, Anthony J. Alberg, Elisa V. Bandera, Jill S. Barnholtz-Sloan, Melissa Bondy, Sydnee Crankshaw, Ellen Funkhouser, Patricia G. Moorman, Edward S. Peters, Paul Terry, Frances Wang, Julie J. Ruterbusch, Ann G. Schwartz, Michele L. Cote

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

BACKGROUND: The association between common benign gynecologic conditions and ovarian cancer remains under-studied in African Americans. Therefore, we examine the association between self-reported history of benign gynecologic conditions and epithelial ovarian cancer risk in African-American women. METHODS: Data from a large population-based, multi-center case-control study of epithelial ovarian cancer in African-American women were analyzed to estimate the association between self-reported history of endometriosis, pelvic inflammatory disease (PID), fibroid, and ovarian cyst with epithelial ovarian cancer. Logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (CI) for the associations between individual and composite gynecologic conditions and ovarian cancer. RESULTS: 600 cases and 752 controls enrolled in the African American Cancer Epidemiology Study between 1 December 2010 and 31 December 2015 comprised the study population. After adjusting for potential confounders, a history of endometriosis was associated with ovarian cancer (OR 1.78; 95% CI 1.09-2.90). A non-significant association of similar magnitude was observed with PID (OR 1.33; 95% CI 0.82-2.16), while no association was observed in women with a history of fibroid or ovarian cyst. A positive trend was observed for an increasing number of reported gynecologic conditions (p = 0.006) with consistency across histologic subtypes and among both oral contraceptive users and non-users. CONCLUSION: A self-reported history of endometriosis among African-American women was associated with increased risk of ovarian cancer. Having multiple benign gynecologic conditions also increased ovarian cancer risk.

Original languageEnglish (US)
Pages (from-to)1081-1091
Number of pages11
JournalCancer causes & control : CCC
Volume29
Issue number11
DOIs
StatePublished - Nov 1 2018

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Keywords

  • African-American
  • African-American Cancer Epidemiology Study (AACES)
  • Endometriosis
  • Ovarian cancer
  • Ovarian cyst
  • Pelvic inflammatory disease (PID)
  • Uterine fibroid

Cite this

Park, H. K., Schildkraut, J. M., Alberg, A. J., Bandera, E. V., Barnholtz-Sloan, J. S., Bondy, M., Crankshaw, S., Funkhouser, E., Moorman, P. G., Peters, E. S., Terry, P., Wang, F., Ruterbusch, J. J., Schwartz, A. G., & Cote, M. L. (2018). Benign gynecologic conditions are associated with ovarian cancer risk in African-American women: a case-control study. Cancer causes & control : CCC, 29(11), 1081-1091. https://doi.org/10.1007/s10552-018-1082-4