Bepridil inhibition of sodium current in rat hippocampal CA1 neurons

Hui Juan Hu, Dong Mei Yang, De Zai Dai, Cai Hong Wu, Pei Ai Zhou

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


AIM: To study the effects of bepridil on sodium current in mt hippocampal neurons. METHODS: All experiments were performed on acutely isolated hippocampal pyramidal neurons by means of whole-cell patch-clamp techniques. Recording media contained ion channel blockers to allow the selective activation of voltage-dependent sodium currents. RESULTS: Bepridil reduced the amplitudes of sodium current in time- and concentration-dependent manners. The half-blocking time was about 10 min in bepridil 10 μmol · L- 1, and IC50 was 2.6 (2.3 - 2.9) μmol · L-1. Bepridil 10 μmol · L-1 shifted the maximal activation of sodium current from - 50 mV to - 40 mV, and the characteristic voltage of inactivation from - 71 mV to -89 mV without changing the slope factor. CONCLUSION: Bepridil blocked voltage-dependent sodium current of hippocampal CA1 neurons and might have therapeutic actions for ischemia-induced brain damage.

Original languageEnglish (US)
Pages (from-to)819-823
Number of pages5
JournalActa Pharmacologica Sinica
Issue number9
StatePublished - 1999
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)


  • Bepridil
  • Electrophysiology
  • Hippocampus
  • Patch-clamp techniques
  • Sodium channels


Dive into the research topics of 'Bepridil inhibition of sodium current in rat hippocampal CA1 neurons'. Together they form a unique fingerprint.

Cite this