Better prediction of functional effects for sequence variants

Maximilian Hecht, Yana Bromberg, Burkhard Rost

Research output: Contribution to journalArticlepeer-review

307 Scopus citations


Definitions used: Delta, input feature that results from computing the difference feature scores for native amino acid and feature scores for variant amino acid; nsSNP, non-synoymous SNP; PMD, Protein Mutant Database; SNAP, Screening for non-acceptable polymorphisms; SNP, single nucleotide polymorphism; variant, any amino acid changing sequence variant.

Original languageEnglish (US)
Article numberS1
JournalBMC genomics
Issue number8
StatePublished - Jun 18 2015

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Genetics


  • From sequence
  • Functional effect prediction
  • Neural network
  • SNP effect
  • Variant effect


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