Bgp, a secreted glycosaminoglycan-binding protein of Borrelia burgdorferi strain N40, displays nucleosidase activity and is not essential for infection of immunodeficient mice

Nikhat Parveen; Kenneth A. Cornell; James L. Bono; Christen Chamberland; Patricia Rosa; John M. Leong

doi:10.1128/IAI.74.5.3016-3020.2006

Bgp, a secreted glycosaminoglycan-binding protein of Borrelia burgdorferi strain N40, displays nucleosidase activity and is not essential for infection of immunodeficient mice

Nikhat Parveen, Kenneth A. Cornell, James L. Bono, Christen Chamberland, Patricia Rosa, John M. Leong

New Jersey Medical School (NJMS), Microbiology

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Bgp, one of the surface-localized glycosaminoglycan-binding proteins of the Lyme disease spirochete, Borrelia burgdorferi, exhibited nucleosidase activity. Infection of SCID mice with B. burgdorferi strain N40 mutants harboring a targeted insertion in bgp and apparently retaining all endogenous plasmids revealed that Bgp is not essential for colonization of immunocompromised mice.

Original language	English (US)
Pages (from-to)	3016-3020
Number of pages	5
Journal	Infection and immunity
Volume	74
Issue number	5
DOIs	https://doi.org/10.1128/IAI.74.5.3016-3020.2006
State	Published - May 2006

All Science Journal Classification (ASJC) codes

Parasitology
Microbiology
Immunology
Infectious Diseases

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10.1128/IAI.74.5.3016-3020.2006

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title = "Bgp, a secreted glycosaminoglycan-binding protein of Borrelia burgdorferi strain N40, displays nucleosidase activity and is not essential for infection of immunodeficient mice",

abstract = "Bgp, one of the surface-localized glycosaminoglycan-binding proteins of the Lyme disease spirochete, Borrelia burgdorferi, exhibited nucleosidase activity. Infection of SCID mice with B. burgdorferi strain N40 mutants harboring a targeted insertion in bgp and apparently retaining all endogenous plasmids revealed that Bgp is not essential for colonization of immunocompromised mice.",

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Bgp, a secreted glycosaminoglycan-binding protein of Borrelia burgdorferi strain N40, displays nucleosidase activity and is not essential for infection of immunodeficient mice. / Parveen, Nikhat; Cornell, Kenneth A.; Bono, James L. et al.

In: Infection and immunity, Vol. 74, No. 5, 05.2006, p. 3016-3020.

Research output: Contribution to journal › Article › peer-review

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AU - Parveen, Nikhat

AU - Cornell, Kenneth A.

AU - Bono, James L.

AU - Chamberland, Christen

AU - Rosa, Patricia

AU - Leong, John M.

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AB - Bgp, one of the surface-localized glycosaminoglycan-binding proteins of the Lyme disease spirochete, Borrelia burgdorferi, exhibited nucleosidase activity. Infection of SCID mice with B. burgdorferi strain N40 mutants harboring a targeted insertion in bgp and apparently retaining all endogenous plasmids revealed that Bgp is not essential for colonization of immunocompromised mice.

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Bgp, a secreted glycosaminoglycan-binding protein of Borrelia burgdorferi strain N40, displays nucleosidase activity and is not essential for infection of immunodeficient mice

Abstract

All Science Journal Classification (ASJC) codes

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