Bicaudal-D, a Drosophila gene involved in developmental asymmetry: Localized transcript accumulation in ovaries and sequence similarity to myosin heavy chain tail domains

B. Suter, L. M. Romberg, R. Steward

Research output: Contribution to journalArticlepeer-review

145 Scopus citations

Abstract

The Bicaudal-D (Bic-D) gene is essential for the differentiation of the oocyte in Drosophila. Dominant gain-of-function mutations result in the formation of double abdomen embryos. The Bic-D gene was cloned and identified using restriction fragment length polymophisms, Northern analysis, and transformation rescue. Bic-D RNA accumulates in the oocyte during the earliest stages of oogenesis and is localized anteriorly in later stages. The predicted protein contains several extended amphipathic helices, and its similarity to myosin heavy chain tails, paramyosin, and kinesin suggests a similar type of coiled-coil protein interaction.

Original languageEnglish (US)
Pages (from-to)1957-1968
Number of pages12
JournalGenes and Development
Volume3
Issue number12 A
DOIs
StatePublished - 1989
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Genetics
  • Developmental Biology

Keywords

  • Bicaudal-D
  • RNA localization
  • amphipathic helices
  • myosin

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