Bio-Instructive Scaffolds for Skeletal Muscle Regeneration: Conductive Materials

J. W. Freeman, D. P. Browe

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Skeletal muscle accounts for roughly 35-45% of total body mass in adult humans and is responsible for voluntary body movements and the maintenance of posture. Large volume deficiencies in skeletal muscle, caused by traumatic injury and surgery, can be debilitating and currently have no viable treatment options. Tissue engineers may be able to regrow muscle using biomaterial scaffolds, which attempt to mimic the native extracellular matrix of muscle tissue. One promising area of research within muscle scaffolds is the use of conductive biomaterials, or biomaterials that can carry an electric current. Since muscle is an electrically excitable tissue, the use of conductive biomaterials may facilitate myoblast communication, growth, and development. This chapter summarizes the use of conductive biomaterials in research for skeletal muscle tissue engineering.

Original languageEnglish (US)
Title of host publicationBio-Instructive Scaffolds for Musculoskeletal Tissue Engineering and Regenerative Medicine
PublisherElsevier Inc.
Pages187-199
Number of pages13
ISBN (Electronic)9780128033999
ISBN (Print)9780128033944
DOIs
StatePublished - Jan 1 2017

All Science Journal Classification (ASJC) codes

  • Engineering(all)
  • Materials Science(all)

Keywords

  • Conductive materials
  • Fibrous scaffolds
  • Myoblast differentiation
  • Myoblasts
  • Myotubes
  • Skeletal muscle

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