Bioassay-guided isolation, identification, and quantification of the estrogen-like constituent from PC SPES

Shengmin Sang, Zhihua Liu, Robert T. Rosen, Chi Tang Ho

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

The herbal mixture PC SPES, a dietary supplement for patients with prostate cancer, has been proved to have estrogenic activity in clinical trials. To determine the active components in PC SPES for estrogenic activity, a bioassay-guided fractionation of PC SPES using a functional estrogen receptor (ER) assay led to the isolation and identification of the most active constituent, ethinyl estradiol, together with two flavonones, neobaicalein and tenaxin I. The isolation, identification and quantification of ethinyl estradiol are discussed.

Original languageEnglish (US)
Title of host publicationHerbs
Subtitle of host publicationChallenges in Chemistry and Biology
EditorsMingfu Wang, Chi-Tang Ho, Shengmin Sang, Lucy Sun Hwang
Pages117-125
Number of pages9
StatePublished - Dec 1 2006

Publication series

NameACS Symposium Series
Volume925
ISSN (Print)0097-6156

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

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