Bioavailability and dissolution properties of two commercial digoxin tablets

Paul R. Klink, Rolland I. Poust, John L. Colaizzi, Robert H. McDonald

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21 Scopus citations


Six healthy male subjects were given 0.5 mg of digoxin on three separate occasions in the form of an elixir and two different commercially available brands of compressed tablets. Blood levels were measured by a radioimmunoassay technique at various time intervals up to 48 hr following drug administration. A previously unreported variable in the radioimmunoassay method was found. Varying amounts of digoxin‐free serum added to aqueous samples such as urine or hydroalcoholic solutions led to significant changes in the apparent digoxin concentration measured in the sample. The elixir form gave much higher blood levels than either tablet during the first two sampling times, but the two tablets showed nearly identical blood levels and relative bioavailabilities. A previously reported dissolution rate test method showed wide differences between the two tablets and thus failed to correlate with the similar bioavailabilities observed in vivo.

Original languageEnglish (US)
Pages (from-to)1231-1234
Number of pages4
JournalJournal of Pharmaceutical Sciences
Issue number8
StatePublished - Aug 1974
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science


  • Bioavailability of digoxin tablets and elixir—compared using radioimmunoassay technique, variable in technique reported, tablet bioavailability compared to dissolution rate
  • Digoxin tablets and elixir—comparative bioavailability, variable in radioimmunoassay technique reported, tablet bioavailability compared to dissolution rate
  • Radioimmunoassay—analysis, digoxin blood levels, variable in technique reported


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