BIOCHEMICAL REACTORS FOR POTENTIAL USE IN CANCER CHEMOTHERAPY.

C. Horvath, H. Pedersen, K. Kalghatgi, J. R. Bertino

Research output: Contribution to conferencePaper

Abstract

The discovery of the antineoplastic activity of L-asparaginase has focused attention on the enzymatic degradation of amino acids as a possible tool for cancer chemotherapy. The rationale of this approach is that neoplastic tissues would have difficulty synthesizing adequate amounts of nonessential amino acids to meet their relatively high metabolic demand and therefore must rely on supplementation from exogeneous sources. Considerable effort has been made to remove certain amino acids from the blood in order to bring about the inhibition of tumor growth. The antitumor action of this enzyme presumably results from its ability to impose severe folate deficiency to which rapidly growing tumor cells would be sensitive.

Original languageEnglish (US)
Pages287-290
Number of pages4
StatePublished - Jan 1 1976
Externally publishedYes
EventUnknown conference - New Haven, CT, USA
Duration: May 7 1976May 8 1976

Other

OtherUnknown conference
CityNew Haven, CT, USA
Period5/7/765/8/76

All Science Journal Classification (ASJC) codes

  • Engineering(all)

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  • Cite this

    Horvath, C., Pedersen, H., Kalghatgi, K., & Bertino, J. R. (1976). BIOCHEMICAL REACTORS FOR POTENTIAL USE IN CANCER CHEMOTHERAPY.. 287-290. Paper presented at Unknown conference, New Haven, CT, USA, .