Biodegradable ferulic acid-containing poly(anhydride-ester): Degradation products with controlled release and sustained antioxidant activity

Michelle A. Ouimet, Jeremy Griffin, Ashley L. Carbone-Howell, Wen Hsuan Wu, Nicholas D. Stebbins, Rong Di, Kathryn E. Uhrich

Research output: Contribution to journalArticlepeer-review

85 Scopus citations

Abstract

Ferulic acid (FA) is an antioxidant and photoprotective agent used in biomedical and cosmetic formulations to prevent skin cancer and senescence. Although FA exhibits numerous health benefits, physicochemical instability leading to decomposition hinders its efficacy. To minimize inherent decomposition, a FA-containing biodegradable polymer was prepared via solution polymerization to chemically incorporate FA into a poly(anhydride-ester). The polymer was characterized using nuclear magnetic resonance and infrared spectroscopies. The molecular weight and thermal properties were also determined. In vitro studies demonstrated that the polymer was hydrolytically degradable, thus providing controlled release of the chemically incorporated bioactive with no detectable decomposition. The polymer degradation products were found to exhibit antioxidant and antibacterial activity comparable to that of free FA, and in vitro cell viability studies demonstrated that the polymer is noncytotoxic toward fibroblasts. This renders the polymer a potential candidate for use as a controlled release system for skin care formulations.

Original languageEnglish (US)
Pages (from-to)854-861
Number of pages8
JournalBiomacromolecules
Volume14
Issue number3
DOIs
StatePublished - Mar 11 2013

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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