Biodegradable Hybrid Organic-Inorganic Scaffold for Drug Delivery and Stem Cell Differentiation

Ki-Bum Lee (Inventor), Letao Yang (Inventor)

Research output: Innovation

Abstract

Schematic diagram representing the self assembly of Laminin (ECM) and the MnO2 sheet


Invention Summary:

While regenerative stem cell therapy has been a promising approach for transplant medicine and surgery, there have been challenges due to low transplantation survival rate and poor selectivity in differentiation.

Researchers at Rutgers University developed a biodegradable manganese oxide-polymer hybrid scaffold designed to selectively guide stem cell differentiation while acting as a controlled drug delivery system. The biodegradable manganese oxide layer allows for drug loading and provides a MRI/FRET-based imaging modality to monitor drug release as it degrades.  Varying the ECM proteins promote stem cell differentiation of different cell types and formation of mature cells.

Additionally, the scaffold results in increased neurite outgrowth during neurogenesis. In combination with small molecule drugs, the scaffold enabled functional recovery in an in vivo model study of spinal cord injury.


Market Applications:

  • Stem cell differentiation
  • Regenerative medicine
  • Drug delivery
  • Stem cell therapy
  • Research tools

Advantages:

  • Self-assembly of nanosheets with ECM
  • Efficient drug loading and controlled release
  • MRI/FRET based monitoring of drug release
  • Compatible with other therapeutic techniques
  • Biocompatible
  • Stimuli responsive biodegradation degradation

Intellectual Property & Development Status:

Patent pending. Available for licensing and/or research collaboration. In silico , in vitro and in vivo results.

Original languageEnglish (US)
StatePublished - Jun 2018
Externally publishedYes

Fingerprint

Cell Differentiation
Stem Cells
Cell- and Tissue-Based Therapy
Pharmaceutical Preparations
Intellectual Property
Stem Cell Research
Regenerative Medicine
Neurogenesis
Laminin
Licensure
Drug Delivery Systems
Spinal Cord Injuries
Computer Simulation
Polymers
Survival Rate
Transplantation
Research Personnel
Medicine
Transplants
Research

Cite this

@misc{e0b4d013450147f1a9d09fcac4703ae7,
title = "Biodegradable Hybrid Organic-Inorganic Scaffold for Drug Delivery and Stem Cell Differentiation",
abstract = "Schematic diagram representing the self assembly of Laminin (ECM) and the MnO2 sheet Invention Summary: While regenerative stem cell therapy has been a promising approach for transplant medicine and surgery, there have been challenges due to low transplantation survival rate and poor selectivity in differentiation. Researchers at Rutgers University developed a biodegradable manganese oxide-polymer hybrid scaffold designed to selectively guide stem cell differentiation while acting as a controlled drug delivery system. The biodegradable manganese oxide layer allows for drug loading and provides a MRI/FRET-based imaging modality to monitor drug release as it degrades.  Varying the ECM proteins promote stem cell differentiation of different cell types and formation of mature cells. Additionally, the scaffold results in increased neurite outgrowth during neurogenesis. In combination with small molecule drugs, the scaffold enabled functional recovery in an in vivo model study of spinal cord injury. Market Applications: Stem cell differentiation Regenerative medicine Drug delivery Stem cell therapy Research tools Advantages: Self-assembly of nanosheets with ECM Efficient drug loading and controlled release MRI/FRET based monitoring of drug release Compatible with other therapeutic techniques Biocompatible Stimuli responsive biodegradation degradation Intellectual Property & Development Status: Patent pending. Available for licensing and/or research collaboration. In silico , in vitro and in vivo results.",
author = "Ki-Bum Lee and Letao Yang",
year = "2018",
month = "6",
language = "English (US)",
type = "Patent",

}

Biodegradable Hybrid Organic-Inorganic Scaffold for Drug Delivery and Stem Cell Differentiation. / Lee, Ki-Bum (Inventor); Yang, Letao (Inventor).

Research output: Innovation

TY - PAT

T1 - Biodegradable Hybrid Organic-Inorganic Scaffold for Drug Delivery and Stem Cell Differentiation

AU - Lee, Ki-Bum

AU - Yang, Letao

PY - 2018/6

Y1 - 2018/6

N2 - Schematic diagram representing the self assembly of Laminin (ECM) and the MnO2 sheet Invention Summary: While regenerative stem cell therapy has been a promising approach for transplant medicine and surgery, there have been challenges due to low transplantation survival rate and poor selectivity in differentiation. Researchers at Rutgers University developed a biodegradable manganese oxide-polymer hybrid scaffold designed to selectively guide stem cell differentiation while acting as a controlled drug delivery system. The biodegradable manganese oxide layer allows for drug loading and provides a MRI/FRET-based imaging modality to monitor drug release as it degrades.  Varying the ECM proteins promote stem cell differentiation of different cell types and formation of mature cells. Additionally, the scaffold results in increased neurite outgrowth during neurogenesis. In combination with small molecule drugs, the scaffold enabled functional recovery in an in vivo model study of spinal cord injury. Market Applications: Stem cell differentiation Regenerative medicine Drug delivery Stem cell therapy Research tools Advantages: Self-assembly of nanosheets with ECM Efficient drug loading and controlled release MRI/FRET based monitoring of drug release Compatible with other therapeutic techniques Biocompatible Stimuli responsive biodegradation degradation Intellectual Property & Development Status: Patent pending. Available for licensing and/or research collaboration. In silico , in vitro and in vivo results.

AB - Schematic diagram representing the self assembly of Laminin (ECM) and the MnO2 sheet Invention Summary: While regenerative stem cell therapy has been a promising approach for transplant medicine and surgery, there have been challenges due to low transplantation survival rate and poor selectivity in differentiation. Researchers at Rutgers University developed a biodegradable manganese oxide-polymer hybrid scaffold designed to selectively guide stem cell differentiation while acting as a controlled drug delivery system. The biodegradable manganese oxide layer allows for drug loading and provides a MRI/FRET-based imaging modality to monitor drug release as it degrades.  Varying the ECM proteins promote stem cell differentiation of different cell types and formation of mature cells. Additionally, the scaffold results in increased neurite outgrowth during neurogenesis. In combination with small molecule drugs, the scaffold enabled functional recovery in an in vivo model study of spinal cord injury. Market Applications: Stem cell differentiation Regenerative medicine Drug delivery Stem cell therapy Research tools Advantages: Self-assembly of nanosheets with ECM Efficient drug loading and controlled release MRI/FRET based monitoring of drug release Compatible with other therapeutic techniques Biocompatible Stimuli responsive biodegradation degradation Intellectual Property & Development Status: Patent pending. Available for licensing and/or research collaboration. In silico , in vitro and in vivo results.

UR - http://rutgers.technologypublisher.com/tech/Biodegradable_Hybrid_Organic-Inorganic_Scaffold_for_Drug_Delivery_and_Stem_Cell_Differentiation

M3 - Innovation

ER -