Bioequivalency of doxycycline products

Edward J. Antal, James M. Jaffe, Holland I. Poust, John L. Colaizzi

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The bioavailability of three different brands and three different dosage forms of doxycycline was studied in normal subjects. Single doses, equivalent to 200 mg of doxycycline, were administered to six subjects in a crossover design as the innovator's intravenous solution given orally (Treatment A), the innovator's capsule product (Treatment B), a noninnovator's capsule product (Treatment C), the innovator's oral suspension product (Treatment D), and a second noninnovator's capsule product (Treatment E). All dosage forms contained doxycycline as the hyclate, except the suspension which contained the nonhyclate form. Serum levels were determined periodically over 48 hr, and cumulative urinary excretion was measured concurrently over a 120‐hr collection period. No statistically significant differences were observed in any in vivo indicator of bioequivalence when the three capsule products were compared. Consequently, they were judged to be bioequivalent. When these capsule products were compared to the oral solution, no statistically significant differences were observed. However, when the capsules and the suspension were compared, statistically significant differences were found in the rate of absorption. In vitro dissolution tests were also conducted on the three brands of capsules, and times required to achieve 50% dissolution showed rank‐order correlation with corresponding absorption rate constants.

Original languageEnglish (US)
Pages (from-to)2015-2018
Number of pages4
JournalJournal of Pharmaceutical Sciences
Volume64
Issue number12
DOIs
StatePublished - Dec 1975
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Keywords

  • Bioavailability—doxycycline products, three different brands and three different dosage forms
  • Doxycycline products—bioavailability, three different brands and three different dosage forms

Fingerprint Dive into the research topics of 'Bioequivalency of doxycycline products'. Together they form a unique fingerprint.

Cite this