Biology and Mechanisms of Action of the Vitamin D Hormone

J. Wesley Pike, Sylvia Christakos

Research output: Contribution to journalReview articlepeer-review

51 Scopus citations

Abstract

The central role of hormonal 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] is to regulate calcium and phosphorus homeostasis via actions in intestine, kidney, and bone. These and other actions in many cell types not involved in mineral metabolism are mediated by the vitamin D receptor. Recent studies using genome-wide scale techniques have extended fundamental ideas regarding vitamin D–mediated control of gene expression while simultaneously revealing a series of new concepts. This article summarizes the current view of the biological actions of the vitamin D hormone and focuses on new concepts that drive the understanding of the mechanisms through which vitamin D operates.

Original languageEnglish (US)
Pages (from-to)815-843
Number of pages29
JournalEndocrinology and Metabolism Clinics of North America
Volume46
Issue number4
DOIs
StatePublished - Dec 2017

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Keywords

  • Calcemic hormones
  • Genetic linkage
  • Genome-wide principles
  • Mineral homeostasis
  • RANKL
  • Target genes
  • Transcription
  • Transient receptor potential vanilloid type-6 (TRPV6)

Fingerprint Dive into the research topics of 'Biology and Mechanisms of Action of the Vitamin D Hormone'. Together they form a unique fingerprint.

Cite this