Biology and Mechanisms of Action of the Vitamin D Hormone

J. Wesley Pike, Sylvia Christakos

Research output: Contribution to journalReview articlepeer-review

173 Scopus citations


The central role of hormonal 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] is to regulate calcium and phosphorus homeostasis via actions in intestine, kidney, and bone. These and other actions in many cell types not involved in mineral metabolism are mediated by the vitamin D receptor. Recent studies using genome-wide scale techniques have extended fundamental ideas regarding vitamin D–mediated control of gene expression while simultaneously revealing a series of new concepts. This article summarizes the current view of the biological actions of the vitamin D hormone and focuses on new concepts that drive the understanding of the mechanisms through which vitamin D operates.

Original languageEnglish (US)
Pages (from-to)815-843
Number of pages29
JournalEndocrinology and Metabolism Clinics of North America
Issue number4
StatePublished - Dec 2017

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


  • Calcemic hormones
  • Genetic linkage
  • Genome-wide principles
  • Mineral homeostasis
  • Target genes
  • Transcription
  • Transient receptor potential vanilloid type-6 (TRPV6)


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