Biology and Mechanisms of Action of the Vitamin D Hormone

J. Wesley Pike; Sylvia Christakos

doi:10.1016/j.ecl.2017.07.001

Biology and Mechanisms of Action of the Vitamin D Hormone

J. Wesley Pike, Sylvia Christakos

New Jersey Medical School (NJMS), Biochemistry

Research output: Contribution to journal › Review article › peer-review

173 Scopus citations

Abstract

The central role of hormonal 1,25-dihydroxyvitamin D₃ [1,25(OH)₂D₃] is to regulate calcium and phosphorus homeostasis via actions in intestine, kidney, and bone. These and other actions in many cell types not involved in mineral metabolism are mediated by the vitamin D receptor. Recent studies using genome-wide scale techniques have extended fundamental ideas regarding vitamin D–mediated control of gene expression while simultaneously revealing a series of new concepts. This article summarizes the current view of the biological actions of the vitamin D hormone and focuses on new concepts that drive the understanding of the mechanisms through which vitamin D operates.

Original language	English (US)
Pages (from-to)	815-843
Number of pages	29
Journal	Endocrinology and Metabolism Clinics of North America
Volume	46
Issue number	4
DOIs	https://doi.org/10.1016/j.ecl.2017.07.001
State	Published - Dec 2017

All Science Journal Classification (ASJC) codes

Endocrinology, Diabetes and Metabolism
Endocrinology

Keywords

Calcemic hormones
Genetic linkage
Genome-wide principles
Mineral homeostasis
RANKL
Target genes
Transcription
Transient receptor potential vanilloid type-6 (TRPV6)

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10.1016/j.ecl.2017.07.001

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title = "Biology and Mechanisms of Action of the Vitamin D Hormone",

abstract = "The central role of hormonal 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] is to regulate calcium and phosphorus homeostasis via actions in intestine, kidney, and bone. These and other actions in many cell types not involved in mineral metabolism are mediated by the vitamin D receptor. Recent studies using genome-wide scale techniques have extended fundamental ideas regarding vitamin D–mediated control of gene expression while simultaneously revealing a series of new concepts. This article summarizes the current view of the biological actions of the vitamin D hormone and focuses on new concepts that drive the understanding of the mechanisms through which vitamin D operates.",

keywords = "Calcemic hormones, Genetic linkage, Genome-wide principles, Mineral homeostasis, RANKL, Target genes, Transcription, Transient receptor potential vanilloid type-6 (TRPV6)",

author = "Pike, {J. Wesley} and Sylvia Christakos",

note = "Funding Information: The work cited in this article was supported by numerous grants from the NIH to J.W. Pike and S. Christakos. The authors wish to thank past and current members of their laboratories for their contributions to the individual work described here and the numerous senior collaborators who have also been involved in specific aspects of this research. We also acknowledge Laura Vanderploeg and Puneet Dhawan for artistic contributions to this article. Publisher Copyright: {\textcopyright} 2017 Elsevier Inc.",

year = "2017",

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doi = "10.1016/j.ecl.2017.07.001",

language = "English (US)",

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T1 - Biology and Mechanisms of Action of the Vitamin D Hormone

AU - Pike, J. Wesley

AU - Christakos, Sylvia

N1 - Funding Information: The work cited in this article was supported by numerous grants from the NIH to J.W. Pike and S. Christakos. The authors wish to thank past and current members of their laboratories for their contributions to the individual work described here and the numerous senior collaborators who have also been involved in specific aspects of this research. We also acknowledge Laura Vanderploeg and Puneet Dhawan for artistic contributions to this article. Publisher Copyright: © 2017 Elsevier Inc.

PY - 2017/12

Y1 - 2017/12

N2 - The central role of hormonal 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] is to regulate calcium and phosphorus homeostasis via actions in intestine, kidney, and bone. These and other actions in many cell types not involved in mineral metabolism are mediated by the vitamin D receptor. Recent studies using genome-wide scale techniques have extended fundamental ideas regarding vitamin D–mediated control of gene expression while simultaneously revealing a series of new concepts. This article summarizes the current view of the biological actions of the vitamin D hormone and focuses on new concepts that drive the understanding of the mechanisms through which vitamin D operates.

AB - The central role of hormonal 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] is to regulate calcium and phosphorus homeostasis via actions in intestine, kidney, and bone. These and other actions in many cell types not involved in mineral metabolism are mediated by the vitamin D receptor. Recent studies using genome-wide scale techniques have extended fundamental ideas regarding vitamin D–mediated control of gene expression while simultaneously revealing a series of new concepts. This article summarizes the current view of the biological actions of the vitamin D hormone and focuses on new concepts that drive the understanding of the mechanisms through which vitamin D operates.

KW - Calcemic hormones

KW - Genetic linkage

KW - Genome-wide principles

KW - Mineral homeostasis

KW - RANKL

KW - Target genes

KW - Transcription

KW - Transient receptor potential vanilloid type-6 (TRPV6)

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U2 - 10.1016/j.ecl.2017.07.001

DO - 10.1016/j.ecl.2017.07.001

M3 - Review article

C2 - 29080638

AN - SCOPUS:85030479308

SN - 0889-8529

VL - 46

SP - 815

EP - 843

JO - Endocrinology and Metabolism Clinics of North America

JF - Endocrinology and Metabolism Clinics of North America

IS - 4

ER -

Biology and Mechanisms of Action of the Vitamin D Hormone

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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