Biomarkers of Response to Preoperative Chemoradiation in Esophageal Cancers

Rajyalakshmi Luthra, Madan G. Luthra, Julie Izzo, Tsung Teh Wu, Enrique Lopez-Alvarez, Usha Malhotra, In Seon Choi, Li Zhang, Jaffer A. Ajani

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

To identify a panel of biomarkers that predicts response of esophageal cancers to preoperative chemoradiation, our group profiled the gene expression of pretreatment cancer biopsies from patients with esophageal cancer. Six (32%) of these patients had pathologic complete response. All cancers except one that achieved pathologic complete response (83%) clustered in one molecular type (type I), while cancers that achieved less than pathologic complete response with one exception clustered in another molecular type (type II). Activated NF-κB was significantly associated with aggressive pathology. These data indicate that expression analysis of a limited set of biomarkers selected from the list of genes that were differentially regulated between the two subtypes can increase predictive power, and suggest that esophageal cancer with activated NF-κB may result in poor treatment outcome.

Original languageEnglish (US)
Pages (from-to)2-5
Number of pages4
JournalSeminars in oncology
Volume33
Issue numberSUPPL. 11
DOIs
StatePublished - Dec 1 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology

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    Luthra, R., Luthra, M. G., Izzo, J., Wu, T. T., Lopez-Alvarez, E., Malhotra, U., Choi, I. S., Zhang, L., & Ajani, J. A. (2006). Biomarkers of Response to Preoperative Chemoradiation in Esophageal Cancers. Seminars in oncology, 33(SUPPL. 11), 2-5. https://doi.org/10.1053/j.seminoncol.2006.10.004