Biosynthetic origin of aflatoxin G1: Confirmation of sterigmatocystin and lack of confirmation of aflatoxin B1 as precursors

A. Henderberg, J. W. Bennett, L. S. Lee

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


The origin of aflatoxin G1 was studied using mutant strains of Aspergillus parasiticus blocked early in the pathway and by tracing 14C-labelled aflatoxin B1 (AFB1) in wild-type A. flavus and A. parasiticus strains. Sterigmatocystin (ST) was a precursor of AFB1, AFG1 and AFG2 in the four mutants examined. The identity of AFG1 was confirmed by mass spectrometry. No evidence for conversion of AFB1 to AFG1 was found. A rigorously controlled study of conversions of radioactivity based on preparative thin-layer chromatography of aflatoxins demonstrated that low levels of aflatoxin interconversions previously reported in the literature might actually be artifacts.

Original languageEnglish (US)
Pages (from-to)661-667
Number of pages7
JournalJournal of general microbiology
Issue number3
StatePublished - 1988
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Microbiology

Fingerprint Dive into the research topics of 'Biosynthetic origin of aflatoxin G<sub>1</sub>: Confirmation of sterigmatocystin and lack of confirmation of aflatoxin B<sub>1</sub> as precursors'. Together they form a unique fingerprint.

Cite this