Biotic Host–Pathogen Interactions As Major Drivers of Plastid Endosymbiosis

Ugo Cenci, Debashish Bhattacharya, Andreas P.M. Weber, Christophe Colleoni, Agathe Subtil, Steven G. Ball

Research output: Contribution to journalReview article

13 Scopus citations

Abstract

The plastid originated 1.5 billion years ago through a primary endosymbiosis involving a heterotrophic eukaryote and an ancient cyanobacterium. Phylogenetic and biochemical evidence suggests that the incipient endosymbiont interacted with an obligate intracellular chlamydial pathogen that housed it in an inclusion. This aspect of the ménage-à-trois hypothesis (MATH) posits that Chlamydiales provided critical novel transporters and enzymes secreted by the pathogens in the host cytosol. This initiated the efflux of photosynthate to both the inclusion lumen and host cytosol. Here we review the experimental evidence supporting the MATH and focus on chlamydial genes that replaced existing cyanobacterial functions. The picture emerging from these studies underlines the importance of chlamydial host-pathogen interactions in the metabolic integration of the primary plastid.

Original languageEnglish (US)
Pages (from-to)316-328
Number of pages13
JournalTrends in Plant Science
Volume22
Issue number4
DOIs
StatePublished - Apr 1 2017

All Science Journal Classification (ASJC) codes

  • Plant Science

Keywords

  • T3SS
  • bacterial conjugation
  • chlamydia
  • evolution of plastids
  • glycogen metabolism
  • tryptophan synthesis

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