Biotransformation of sterigmatocystin and absence of aflatoxin biotransformation by blocked mutants ofAspergillus parasiticus

John C. Floyd; James C. Mills; J. W. Bennett

doi:10.1016/0147-5975(87)90043-0

Biotransformation of sterigmatocystin and absence of aflatoxin biotransformation by blocked mutants ofAspergillus parasiticus

John C. Floyd, James C. Mills, J. W. Bennett

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Four blocked aflatoxin mutants were used to test biotransformation of sterigmatocystin and aflatoxins. Three blocked anthraquinone-accumulating mutants (avn-1, avr-1, ver-1) were able to convert sterigmatocystin into both B and G aflatoxins. No conversions of sterigmatocystin were observed with autoclaved controls or with the fourth blocked mutant (fan). Under equivalent resting cell conditions, no interconversion of aflatoxins B₁, B₂, G₁, or G₂ was observed byver-1, fan, or autoclaved controls.

Original language	English (US)
Pages (from-to)	109-114
Number of pages	6
Journal	Experimental Mycology
Volume	11
Issue number	2
DOIs	https://doi.org/10.1016/0147-5975(87)90043-0
State	Published - Jun 1987
Externally published	Yes

All Science Journal Classification (ASJC) codes

Applied Microbiology and Biotechnology

Keywords

Aspergillus parasiticus
aflatoxin biosynthesis
aflatoxins
sterigmatocystin

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10.1016/0147-5975(87)90043-0

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@article{b97c313654c4421c8fc7e440d5cc39e7,

title = "Biotransformation of sterigmatocystin and absence of aflatoxin biotransformation by blocked mutants ofAspergillus parasiticus",

abstract = "Four blocked aflatoxin mutants were used to test biotransformation of sterigmatocystin and aflatoxins. Three blocked anthraquinone-accumulating mutants (avn-1, avr-1, ver-1) were able to convert sterigmatocystin into both B and G aflatoxins. No conversions of sterigmatocystin were observed with autoclaved controls or with the fourth blocked mutant (fan). Under equivalent resting cell conditions, no interconversion of aflatoxins B1, B2, G1, or G2 was observed byver-1, fan, or autoclaved controls.",

keywords = "Aspergillus parasiticus, aflatoxin biosynthesis, aflatoxins, sterigmatocystin",

author = "Floyd, {John C.} and Mills, {James C.} and Bennett, {J. W.}",

note = "Funding Information: Portions of this research were supported by a summer grant from the Cancer Society of Greater New Orleans and Cooperative Agreements with the U.S. Department of Agriculture (58-7B30-3-566) and Johns Hopkins University (NIH 5ROlESA1670-007). We thank Louise Lee and Siegfried Christensen for useful discussions, Deepak Bhatnagar for reviewing the manuscript. and Ann Floyd and Tarry1 Ray for typing assistance.",

year = "1987",

month = jun,

doi = "10.1016/0147-5975(87)90043-0",

language = "English (US)",

volume = "11",

pages = "109--114",

journal = "Experimental Mycology",

issn = "0147-5975",

publisher = "Academic Press Inc.",

number = "2",

}

TY - JOUR

T1 - Biotransformation of sterigmatocystin and absence of aflatoxin biotransformation by blocked mutants ofAspergillus parasiticus

AU - Floyd, John C.

AU - Mills, James C.

AU - Bennett, J. W.

N1 - Funding Information: Portions of this research were supported by a summer grant from the Cancer Society of Greater New Orleans and Cooperative Agreements with the U.S. Department of Agriculture (58-7B30-3-566) and Johns Hopkins University (NIH 5ROlESA1670-007). We thank Louise Lee and Siegfried Christensen for useful discussions, Deepak Bhatnagar for reviewing the manuscript. and Ann Floyd and Tarry1 Ray for typing assistance.

PY - 1987/6

Y1 - 1987/6

N2 - Four blocked aflatoxin mutants were used to test biotransformation of sterigmatocystin and aflatoxins. Three blocked anthraquinone-accumulating mutants (avn-1, avr-1, ver-1) were able to convert sterigmatocystin into both B and G aflatoxins. No conversions of sterigmatocystin were observed with autoclaved controls or with the fourth blocked mutant (fan). Under equivalent resting cell conditions, no interconversion of aflatoxins B1, B2, G1, or G2 was observed byver-1, fan, or autoclaved controls.

AB - Four blocked aflatoxin mutants were used to test biotransformation of sterigmatocystin and aflatoxins. Three blocked anthraquinone-accumulating mutants (avn-1, avr-1, ver-1) were able to convert sterigmatocystin into both B and G aflatoxins. No conversions of sterigmatocystin were observed with autoclaved controls or with the fourth blocked mutant (fan). Under equivalent resting cell conditions, no interconversion of aflatoxins B1, B2, G1, or G2 was observed byver-1, fan, or autoclaved controls.

KW - Aspergillus parasiticus

KW - aflatoxin biosynthesis

KW - aflatoxins

KW - sterigmatocystin

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U2 - 10.1016/0147-5975(87)90043-0

DO - 10.1016/0147-5975(87)90043-0

M3 - Article

AN - SCOPUS:0023574573

SN - 0147-5975

VL - 11

SP - 109

EP - 114

JO - Experimental Mycology

JF - Experimental Mycology

IS - 2

ER -

Biotransformation of sterigmatocystin and absence of aflatoxin biotransformation by blocked mutants ofAspergillus parasiticus

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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