@article{25bfc5c5e56a4c8fb5784f23b6776efb,
title = "Bitter melon extract attenuating hepatic steatosis may be mediated by FGF21 and AMPK/Sirt1 signaling in mice",
abstract = "We sought to evaluate the effects of Momordica charantia (bitter melon, BM) extract on insulin sensitivity, NAFLD, hepatic FGF21 and AMPK signaling in mice fed a high-fat diet. Male C57/B6 mice were randomly divided into HFD and HFD supplementation with BM for 12 week. Body weight, plasma glucose, FGF21 and insulin levels, hepatic FGF21 and AMPK signaling proteins were measured. The results showed that plasma FGF21 and insulin concentrations were significantly decreased and hepatic FGF21 content was significantly down-regulated, while FGF receptors 1, 3 and 4 (FGFR1, FGFR3 and FGFR4) were greatly up-regulated in BM group compared to the HFD group (P < 0.05 and P < 0.01). BM also significantly increased hepatic AMPK p, AMPK α1 AMPK α2 and Sirt1 content compared to the HFD mice. We, for the first time, demonstrated that BM extract attenuated hepatic steatosis in mice by enhancing hepatic FGF21 and AMPK/Sirt1 signaling.",
author = "Yongmei Yu and Zhang, {Xian H.} and Blake Ebersole and David Ribnicky and Wang, {Zhong Q.}",
note = "Funding Information: The authors would like to thank Verdure Sciences Company (Noblesville, IN) for kindly providing BM extract, and Dr. Sanjay Patel from Pharmanza Herbals, India who did the BM extract analysis. We also are grateful to Dr. Donald Ingram and Dr. Jeffrey Gimble for their valuable comments and feedback. Authors also thank Dr. William T. Cefalu for his help; we could not finish this project without his selfless support. This project used Genomics core facilities supported in part by COBRE (NIH P20-RR021945) and NORC (NIH 1P30-DK072476) center grants from the National Institutes of Health. We acknowledge the assistance of Ms. Laura Dallam (Pennington Biomedical Research Center) in preparing the manuscript. This study was supported by pilot grants from Botanical Research Center at Pennington Biomedical Research Center, P50AT002776-01 from the National Center for Complementary and Alternative Medicine and the Office of Dietary Supplements, which funds the Botanical Research Center of Pennington Biomedical Research Center and the Biotech Center of Rutgers University.",
year = "2013",
month = nov,
day = "5",
doi = "10.1038/srep03142",
language = "English (US)",
volume = "3",
journal = "Scientific reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
}