Bladder tumors in two young males occupationally exposed to MBOCA

Elizabeth Ward, William Halperin, Michael Thun, H. Barton Grossman, Burton Fink, Leopold Koss, Ana Maria Osorio, Paul Schulte

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36 Scopus citations


MBOCA (4,4′ methylenebis (2‐chloroaniline) is a structural analogue of benzidine and is carcinogenic in mice, rats, and dogs. MBOCA has not yet been demonstrated to be carcinogenic in humans and is not regulated as an occupational carcinogen in the United States. We report two noninvasive papillary tumors of the bladder identified in a screening study of 540 workers exposed to MBOCA during its production at a Michigan chemical plant from 1968 to 1979. Both tumors occurred in men under 30 years old who had never smoked. Although the prevalence of grade 1‐2 tumors among asymptomatic males in this age group is unknown, the incidence of clinically apparent tumors on U.S. males aged 25‐29 is only 1 per 100,000 per year. The detection of the two tumors in young, nonsmoking males is consistent with the hypothesis that MBOCA induces bladder neoplasms in humans.

Original languageEnglish (US)
Pages (from-to)267-272
Number of pages6
JournalAmerican journal of industrial medicine
Issue number3
StatePublished - 1988

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health


  • 4,4′ methylenebis (2‐chloroaniline)
  • bladder cancer
  • occupation


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