Iontophoresis of direct current (DC) with various pulse waveform modes was used to facilitate and regulate the transdermal delivery of insulin in order to control blood glucose levels in diabetic rats. It was found that a considerable reduction in blood glucose levels can be achieved by a lower current intensity and shorter application time, using a pulse current instead of simple direct current. The effect of DC pulse waveform parameters on the blood glucose control in diabetic rats was also investigated. Frequency and current intensity were found to be the two important parameters. Blood glucose levels were observed to be better controlled when higher frequency with an on/off ratio of 1:1 was used.
All Science Journal Classification (ASJC) codes
- Pharmaceutical Science