Blood glucose control in diabetic rats by transdermal iontophoretic delivery of insulin

Liu Jue-Chen, Sun Ying, Ovais Siddiqui, Chien Yie W., Shi Wei-min, Li John

Research output: Contribution to journalArticlepeer-review

80 Scopus citations

Abstract

Iontophoresis of direct current (DC) with various pulse waveform modes was used to facilitate and regulate the transdermal delivery of insulin in order to control blood glucose levels in diabetic rats. It was found that a considerable reduction in blood glucose levels can be achieved by a lower current intensity and shorter application time, using a pulse current instead of simple direct current. The effect of DC pulse waveform parameters on the blood glucose control in diabetic rats was also investigated. Frequency and current intensity were found to be the two important parameters. Blood glucose levels were observed to be better controlled when higher frequency with an on/off ratio of 1:1 was used.

Original languageEnglish (US)
Pages (from-to)197-204
Number of pages8
JournalInternational Journal of Pharmaceutics
Volume44
Issue number1-3
DOIs
StatePublished - Jun 1988
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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