Blood pressure, salivary cortisol, and inflammatory cytokine outcomes in senior female cancer survivors enrolled in a tai chi chih randomized controlled trial

Rebecca A. Campo, Kathleen C. Light, Kathleen O’Connor, Yoshio Nakamura, David Lipschitz, Paul C. LaStayo, Lisa M. Pappas, Kenneth M. Boucher, Michael R. Irwin, Harry R. Hill, Thomas B. Martins, Neeraj Agarwal, Anita Y. Kinney

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Purpose: Older cancer survivors are a vulnerable population due to an increased risk for chronic diseases (e.g., cardiovascular disease) compounded with treatment late-effects and declines in physical functioning. Therefore, interventions that reduce chronic disease risk factors (i.e., blood pressure, chronic inflammation, and cortisol) are important in this population. Tai chi chih (TCC) is a mind-body exercise associated with reductions in chronic disease risk factors, but has not been examined with older cancer survivors. In a feasibility randomized controlled trial of TCC, we examined secondary outcomes of blood pressure, salivary cortisol, and inflammatory cytokines (interleukin (IL)-6, IL-12, tumor necrosis factor-α, IL-10, IL-4) due to their implications in chronic diseases. Methods: Sixty-three senior female cancer survivors (M age = 67 years, SD = 7.15) with physical functioning limitations (SF-12 physical functioning ≤80 or role-physical ≤72) were randomized to 12-weeks (60-min, three times a week) of TCC or Health Education control (HEC) classes. Resting blood pressure, 1-day salivary cortisol samples, and fasting plasma samples for cytokine multiplex assays were collected at baseline and 1-week post-intervention. Results: Controlling for baseline values, the TCC group had significantly lower systolic blood pressure (SBP, p = 0.002) and cortisol area-under-curve (AUC, p = 0.02) at post-intervention than the HEC group. There was no intervention effect on inflammatory cytokines (p’s > 0.05). Conclusions: This TCC feasibility trial was associated with significant reductions in SBP and cortisol AUC in senior female cancer survivors. Larger, definitive trials are needed to confirm these findings. Implications for Cancer Survivors: Senior survivors’ have an increased risk for chronic diseases; however, TCC interventions may help reduce associated risk factors.

Original languageEnglish (US)
Pages (from-to)115-125
Number of pages11
JournalJournal of Cancer Survivorship
Volume9
Issue number1
DOIs
StatePublished - Feb 26 2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Oncology(nursing)

Keywords

  • Blood pressure
  • Cortisol
  • Inflammatory cytokines
  • Randomized controlled trial
  • Senior cancer survivors
  • Tai Chi Chih

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