TY - JOUR
T1 - Body size in early life and breast cancer risk in African American and European American women.
AU - Bandera, Elisa V.
AU - Chandran, Urmila
AU - Zirpoli, Gary
AU - Ciupak, Gregory
AU - Bovbjerg, Dana H.
AU - Jandorf, Lina
AU - Pawlish, Karen
AU - Freudenheim, J. L.
AU - Ambrosone, Christine B.
N1 - Funding Information:
Acknowledgments This work was supported by grants from the US Army Medical Research and Material Command (DAMD-17-01-1-0334), the National Cancer Institute (R01 CA100598,P01 CA151135, K22 CA138563, P30CA072720, P30 CA016056), the Breast Cancer Research Foundation and a gift from the Philip L. Hubbell family. The New Jersey State Cancer Registry (NJSCR) is a participant in the Centers for Disease Control and Prevention’s National Program of Cancer Registries and is a National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) Expansion Registry. The NJSCR is supported by the Centers for Disease Control and Prevention under cooperative agreement 1US58DP003931-01 awarded to the New Jersey Department of Health. The collection of New Jersey cancer incidence data is also supported by the National Cancer Institute’s SEER Program under contract N01-PC-2010-00027 and the State of New Jersey. The funding agents played no role in design, in the collection, analysis, and interpretation of data, in the writing of the manuscript, or in the decision to submit the manuscript for publication. We thank the colleagues, physicians and clinical staff in New York and New Jersey who facilitated identification and enrollment of cases into the study: Kandace Amend (i3 Drug Safety), Helena Fur-berg (Memorial Sloan-Kettering Cancer Center), Thomas Rohan and Joseph Sparano (Albert Einstein College of Medicine), Paul Tartter and Alison Estabrook (St. Luke’s Roosevelt Hospital), James Reilly (Kings County Hospital Center), Benjamin Pace, George Raptis, and Christina Weltz (Mount Sinai School of Medicine), Maria Castaldi (Jacob Medical Center), Sheldon Feldman (New York-Presbyterian), and Margaret Kemeny (Queens Hospital Center). We also thank our research personnel at the Rutgers Cancer Institute of New Jersey, Roswell Park Cancer Institute, Mount Sinai School of Medicine, Rutgers School of Public Health, and the New Jersey State Cancer Registry, as well as our African American breast cancer advocates and community partners, and all the women who generously donated their time to participate in the study.
PY - 2013/12
Y1 - 2013/12
N2 - There is growing evidence that body size in early life influences lifetime breast cancer risk, but little is known for African American (AA) women. We evaluated body size during childhood and young adulthood and breast cancer risk among 1,751 cases [979 AA and 772 European American (EA)] and 1,673 controls (958 AA and 715 EA) in the Women's Circle of Health Study. Odds ratio (OR) and 95 % confidence intervals (CI) were computed using logistic regression models while adjusting for potential covariates. Among AA women, being shorter at 7-8 years compared to peers was associated with increased postmenopausal breast cancer risk (OR 1.68, 95 % CI 1.02-2.74), and being heavier at menarche with decreased postmenopausal breast cancer risk, although of borderline significance (OR 0.45, 95 % CI 0.20-1.02). For EA women, being shorter from childhood through adolescence, particularly at menarche, was associated with reduced premenopausal breast cancer risk (OR 0.55, 95 % CI 0.31-0.98). After excluding hormone replacement therapy users, an inverse association with postmenopausal breast cancer was found among EA women reporting to be heavier than their peers at menarche (OR 0.18, 95 % CI 0.04-0.79). The inverse relationship between BMI at age 20 and breast cancer risk was stronger and only statistically significant in EA women. No clear association with weight gain since age 20 was found. Findings suggest that the impact of childhood height on breast cancer risk may differ for EA and AA women and confirm the inverse association previously reported in EA populations with adolescent body fatness, in AA women.
AB - There is growing evidence that body size in early life influences lifetime breast cancer risk, but little is known for African American (AA) women. We evaluated body size during childhood and young adulthood and breast cancer risk among 1,751 cases [979 AA and 772 European American (EA)] and 1,673 controls (958 AA and 715 EA) in the Women's Circle of Health Study. Odds ratio (OR) and 95 % confidence intervals (CI) were computed using logistic regression models while adjusting for potential covariates. Among AA women, being shorter at 7-8 years compared to peers was associated with increased postmenopausal breast cancer risk (OR 1.68, 95 % CI 1.02-2.74), and being heavier at menarche with decreased postmenopausal breast cancer risk, although of borderline significance (OR 0.45, 95 % CI 0.20-1.02). For EA women, being shorter from childhood through adolescence, particularly at menarche, was associated with reduced premenopausal breast cancer risk (OR 0.55, 95 % CI 0.31-0.98). After excluding hormone replacement therapy users, an inverse association with postmenopausal breast cancer was found among EA women reporting to be heavier than their peers at menarche (OR 0.18, 95 % CI 0.04-0.79). The inverse relationship between BMI at age 20 and breast cancer risk was stronger and only statistically significant in EA women. No clear association with weight gain since age 20 was found. Findings suggest that the impact of childhood height on breast cancer risk may differ for EA and AA women and confirm the inverse association previously reported in EA populations with adolescent body fatness, in AA women.
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U2 - 10.1007/s10552-013-0302-1
DO - 10.1007/s10552-013-0302-1
M3 - Article
C2 - 24113797
AN - SCOPUS:84902613118
VL - 24
SP - 2231
EP - 2243
JO - Cancer Causes and Control
JF - Cancer Causes and Control
SN - 0957-5243
IS - 12
ER -